Natural history and predictors of disease severity in chronic hepatitis C
Natural history and predictors of disease severity in chronic hepatitis C
复制标题
DOI：
10.1016/j.jhep.2005.11.009
复制
发表时间：
2006-01-01
影响因子：
25.7
通讯作者：
Poynard, T
中科院分区：
文献类型：
--
作者：
Massard, J;Ratziu, V;Poynard, T
肝硬变是慢性丙型肝炎患者纤维化进展的终末期结果。从感染到肝硬变的中位数时间为30年，具有很高的个体差异性，这一点现在得到了更好的理解。有几个因素已被清楚地证明与纤维化进展率有关：感染持续时间、年龄、男性、饮酒、艾滋病毒合并感染和低CD4计数。脂肪变性、超重和糖尿病等代谢状况正在成为纤维化形成的独立辅助因素。最近对非侵入性生物标志物的验证应该有助于研究大人群中的纤维化进展。(C)2005年欧洲肝脏研究协会。爱思唯尔出版，版权所有。
Cirrhosis is the end-stage consequence of fibrosis progression in patients with chronic hepatitis C. The median time from infection to cirrhosis is 30 years, with a high inter-individual variability, which is now better understood. Several factors have been clearly shown to be associated with fibrosis progression rate: duration of infection, age, male gender, alcohol consumption, HIV co-infection and low CD4 count. Metabolic conditions such as steatosis, being overweight and diabetes are emerging as independent co-factors of fibrogenesis. The recent validation of non-invasive biomarkers should facilitate the study of fibrosis progression in large populations. (c) 2005 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.