A low level of C-reactive protein in Japanese adults and its association with cardiovascular risk factors: The Japan NCVC-Collaborative Inflammation Cohort (JNIC) Study
A low level of C-reactive protein in Japanese adults and its association with cardiovascular risk factors: The Japan NCVC-Collaborative Inflammation Cohort (JNIC) Study
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DOI：
10.1016/j.atherosclerosis.2006.07.032
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发表时间：
2007-09-01
期刊：
影响因子：
5.3
通讯作者：
Tsushima, Motoo
中科院分区：
文献类型：
--
作者：
Saito, Isao;Sato, Shinichi;Tsushima, Motoo
超敏C反应蛋白(hs-CRP)水平因种族和民族而异。我们研究了日本普通人群中hs-CRP水平及其与心血管危险因素的关系。日本国家心血管中心(NCVC)-合作炎症队列(JNIC)研究在2002-2004年间从日本的7个社区招募了5213名男性和7071名女性，年龄=40岁。用国际血浆蛋白标准物质CRM470校准的散射比浊法测定Hs-CRP。传统的心血管危险因素及其聚集在多变量Logistic模型中被研究，按超重状况分层。男性和女性高敏C反应蛋白水平的中位数分别为0.60和0.45 mg/L。血清hs-CRP1.0、1.0~3.0和3.0 mg/L水平男性分别为67.4%、22.0%和10.6%，女性分别为76.3%、16.7%和7.0%。超敏C反应蛋白水平与传统危险因素呈显著线性相关。超重、高血压、血脂异常(仅限男性)、吸烟(仅限男性)和糖尿病(仅限女性)显著导致hs-CRP水平升高。患有高血压、血脂异常和糖尿病的超重个体在男女中hs-CRP水平升高的发生率都很高。日本成年人的hs-CRP水平非常低。代谢危险因素的聚集与超重个体中hs-CRP水平升高有关，特别是在女性中。(C)2006爱思唯尔爱尔兰有限公司。保留所有权利。
High-sensitivity C-reactive protein (hs-CRP) levels vary remarkably by race and ethnic group. We examined hs-CRP levels and their association with cardiovascular risk factors in the Japanese general population. The Japan National Cardiovascular Center (NCVC)-collaborative Inflammation Cohort (JNIC) Study recruited 5213 men and 7071 women aged >= 40 years from seven communities in Japan during 2002-2004. hs-CRP was measured using nephelometry calibrated with CRM 470, the international plasma protein reference material. Traditional cardiovascular risk factors and their aggregation were studied in multivariate logistic models, stratified by overweight status. Median hs-CRP levels in men and women were 0.60 and 0.45 mg/L, respectively. The percentage of subjects with hs-CRP levels < 1.0, 1.0-3.0, and >3.0 mg/L was 67.4%, 22.0%, and 10.6% in men, respectively, and 76.3%, 16.7%, and 7.0% in women. hs-CRP levels showed significant linear associations with traditional risk factors. Overweight, hypertension, dyslipidemia (men only), smoking (men only), and diabetes (women only) contributed significantly to elevated hs-CRP levels. Overweight individuals with hypertension, dyslipidemia, and diabetes had a high prevalence of elevated hs-CRP levels in both sexes. Japanese adults have very low hs-CRP levels. An aggregation of metabolic risk factors is associated with elevated hs-CRP levels among overweight individuals, particularly in women. (C) 2006 Elsevier Ireland Ltd. All rights reserved.