Human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) infection in men receiving treatment for HIV-1 infection.
Human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) infection in men receiving treatment for HIV-1 infection.
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接受 HIV-1 感染治疗的男性感染人类疱疹病毒 8（卡波西肉瘤相关疱疹病毒）。
DOI：
10.1097/00126334-199912010-00003
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
Schooley,RT
中科院分区：
文献类型：
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作者：
Campbell,TB;Fitzpatrick,L;MaWhinney,S;Zhang,X;Schooley,RT
目的：了解科罗拉多丹佛市HIV-1感染者中人类疱疹病毒8型（HHV-8）感染的流行情况。设计：横断面分析方法：收集216例HIV-1感染者的血样。用免疫荧光法检测潜伏相关核抗原（拉娜）抗体，用聚合酶链反应扩增法检测外周血单个核细胞（PBMC）中HHV-8的存在。结果：在无卡波西肉瘤（KS）的HIV-1感染者中，HHV-8感染率为46%（95%可信区间0.39-0.52）。拉娜血清阳性在KS受试者和非KS受试者中均很常见（69%对42%; p=. 06），但外周血中HHV-8 DNA的检测与KS的诊断密切相关（44%对10%; p=. 001）。在一个单变量分析的研究对象没有KS，无论是拉娜血清阳性的几率，也没有检测到HHV-8 DNA在PBMC中是显着的CD 4+淋巴细胞计数，HIV-1病毒载量，使用三种药物抗逆转录病毒治疗方案或以前发生的非KS艾滋病相关conditions.Conclusion：虽然抗体HHV-8是常见的HIV-1感染的男性，HHV-8 DNA在PBMC中的检测是罕见的，并与卡波西肉瘤的诊断。
Objective:To determine the prevalence of human herpesvirus 8 (HHV-8) infection in men treated for HIV-1 infection in Denver, Colorado.Design:Cross-sectional analysisMethods:Blood samples were obtained from 216 HIV-1-infected men. Antibody to latency-associated nuclear antigen (LANA) was detected by an immunofluorescent assay and the presence of HHV-8 in peripheral blood mononuclear cells (PBMC) was detected by polymerase chain reaction amplification.Results:Among HIV-1-infected men who did not have Kaposi's sarcoma (KS), prevalence of HHV-8 infection was 46%(95% confidence interval [CI], 0.39-0.52). LANA seropositivity was common both among subjects with KS and subjects without KS (69% versus 42%; p=. 06), but detection of HHV-8 DNA in peripheral blood was strongly associated with a diagnosis of KS (44% versus 10%; p=. 001). In a univariate analysis of study subjects without KS, neither the odds of LANA seropositivity nor detection of HHV-8 DNA in PBMC was significant for CD4+ lymphocyte count, HIV-1 virus load, the use of three drug antiretroviral regimens or the prior occurrence of non-KS AIDS-related conditions.Conclusion:Although antibodies to HHV-8 are common among HIV-1-infected men, detection of HHV-8 DNA in PBMC is uncommon and is associated with a diagnosis of Kaposi's sarcoma.
DOI：
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发表时间：
1971
期刊：
影响因子：
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作者：
John B. Carroll;P. Davies;B. Richman
通讯作者：
B. Richman