Relationships between sleep disturbances and gastroesophageal reflux disease in Asian sleep clinic referrals
Relationships between sleep disturbances and gastroesophageal reflux disease in Asian sleep clinic referrals
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DOI：
10.1016/j.jpsychores.2013.10.004
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发表时间：
2013-12-01
影响因子：
4.7
通讯作者：
Kim, Nayoung
中科院分区：
文献类型：
--
作者：
Ju, Gawon;Yoon, In-Young;Kim, Nayoung
目的：关于胃食管反流病（GERD）和睡眠呼吸暂停综合征（SAS）之间关系的研究报告了相互矛盾的结果，并且没有注意到GERD和其他睡眠障碍之间的关系。该研究的目的是评估胃食管反流病和各方面的sleep disturbances.Methods的关系：共564名受试者谁被称为睡眠实验室参加了这项研究。他们接受了夜间多导睡眠图（NPSG），并被要求完成GERD问卷。问卷包括14个项目，包括7个反流症状的问题，即烧心，反流，胸痛，声音嘶哑，球形感，咳嗽和上腹部疼痛。每周至少报告一次胃灼热或反酸的受试者被归类为有GERD.Results：在564名参与者中，51名受试者（9.0%）被诊断为有GERD。与非GERD患者相比，GERD患者在Beck抑郁量表（p <0.01）、埃普沃思嗜睡量表（p = 0.03）、睡眠质量指数（p <0.01）、NPSG中更多的自发觉醒和更多的饮酒方面得分更高。GERD、SAS相关变量和体重指数（BMI）之间无相关性。GERD与睡眠质量差（校正OR为3.5; 95%CI为1.3-9.3）和抑郁情绪（校正OR为2.8; 95%CI为1.5-5.3）显著相关。结论：主观睡眠质量差和抑郁症状与GERD的发生有关，SAS、BMI与GERD无关。在管理GERD患者时，需要评估精神和睡眠症状并进行适当治疗。(c)2013 Elsevier Inc. All rights reserved.
Objective: Studies on the association between gastroesophageal reflux disease (GERD) and sleep apnea syndrome (SAS) have reported conflicting results, and attention has not been paid to the relationship between GERD and other sleep disorders. The aim of the study was to evaluate the relationship between GERD and various aspects of sleep disturbances.Methods: A total of 564 subjects who were referred to a sleep laboratory were enrolled in the study. They underwent nocturnal polysomnography (NPSG), and they were asked to complete a GERD questionnaire. The questionnaire consisted of 14 items, and included questions on seven reflux symptoms, namely, heartburn, add regurgitation, chest pain, hoarseness, globus sensation, coughing and epigastric soreness. Subjects reporting heartburn or acid regurgitation at least once a week were classified as having GERD.Results: Among 564 participants, 51 subjects (9.0%) were diagnosed as having GERD. GERD patients had higher scores in Beck depression inventory (p < .01), Epworth sleepiness scale (p = .03), Pittsburg sleep quality index (p < .01), more spontaneous arousals in NPSG, and more alcohol consumption than non-GERD patients. There was no association between presence of GERD, SAS-related variables, and body mass index (BMI). GERD was significantly associated with poor sleep quality (adjusted OR, 3.5; 95% CI, 1.3-9.3) and depressed mood (adjusted OR, 2.8; 95% CI, 1.5-5.3).Conclusion: Poor subjective sleep and depressive symptoms are associated with the presence of GERD with no association between SAS, BMI and GERD. In managing patients with GERD, psychiatric and sleep symptoms need to be evaluated and appropriately treated. (c) 2013 Elsevier Inc. All rights reserved.