Association of red blood cell distribution width, systemic-immune-inflammation index and poor cardiovascular outcomes in patients with newly diagnosed hypertension
Association of red blood cell distribution width, systemic-immune-inflammation index and poor cardiovascular outcomes in patients with newly diagnosed hypertension
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DOI：
10.1080/10641963.2022.2079668
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发表时间：
2022-06-02
影响因子：
12.3
通讯作者：
Erturk, Mehmet
中科院分区：
文献类型：
--
作者：
Uzun, Fatih;Guner, Ahmet;Erturk, Mehmet
背景：红细胞分布宽度(RDW)和全身免疫炎症指数(SII)作为预测心血管疾病发病率和死亡率的指标已被广泛研究。本前瞻性研究旨在探讨高血压患者长期主要心脏不良事件(MACEs)与简单血液学指标的关系。方法对1202例新诊断的高血压患者进行研究。女性662例(55.1%)，男性540例(44.9%)，平均年龄53.0±11.4岁。研究的主要终点是长期的MACE，包括心源性死亡、中风和心肌梗死。这是第一个关于高血压患者SII与主要心血管不良结局之间关系的研究。结果89例(8.7%)患者在平均82.2+/-1.3个月的随访期内至少发生一次MACE。465.0(353.4-609.4)vs.584.4(468.9-794.0)x10(3)/亩L，p13.1%(10.4vs.5%；p<；.001)；465x10(3)/亩L(11.8vs.3.1%)。多因素Logistic回归分析显示，SII和RDW是MACEs的独立预测因素。结论RDW和SII是高血压患者长期心血管事件的独立预测因子。这些简单的血液学指标可作为新诊断的HT患者发生MACE的预测指标。
Background Red cell distribution width (RDW) and the systemic immune-inflammation index (SII) have been extensively studied as predictors of morbidity and mortality in several cardiovascular diseases. This prospective study aimed to investigate the relationship between long term major adverse cardiac events (MACEs) and simple hematological parameters in hypertensive patients. Methods The study included a total of 1202 patients with newly diagnosed HT. Of the patients, 662 (55.1%) were female and 540 (44.9%) were male, with a mean age of 53.0 +/- 11.4 years. The primary endpoint of the study was long term MACE, including cardiac death, stroke, and myocardial infarction. This is the first study focusing on the association of SII with major adverse cardiovascular outcomes in patients with HT. Results Eighty-nine patients (8.7%) developed at least one MACE during a mean follow-up period of 82.2 +/- 1.3 months. RDW (13.0 +/- 0.9 vs. 13.5 +/- 1.2%, p < .001) and SII [465.0 (353.4-609.4) vs. 584.4 (468.9-794.0) x10(3)/mu L, p 13.1% (10.4 vs. 5%; p < .001) and in patients with SII>465 x10(3)/mu L (11.8 vs. 3.1%; p < .001). The multivariate logistic regression analysis showed SII and RDW were independent predictors of MACEs. Conclusion The results of the study demonstrated that the RDW and SII were independent predictors of long-term cardiovascular events in hypertensive patients. These simple hematological parameters may be used as prognosticators of MACE in patients with newly diagnosed HT.