Catalytic Asymmetric Sulfenylation of Unprotected 3-Substituted Oxindoles
Catalytic Asymmetric Sulfenylation of Unprotected 3-Substituted Oxindoles
复制标题
未保护的 3-取代羟吲哚的催化不对称磺酰化
DOI：
10.1021/ol3009446
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发表时间：
2012-06-01
期刊：
影响因子：
5.2
通讯作者：
Feng, Xiaoming
中科院分区：
文献类型：
--
作者：
Cai, Yunfei;Li, Jun;Feng, Xiaoming
通过手性N，N-二氧化物-Sc（OTf）（3）配合物和Bronsted碱的协同催化作用，研究了未保护的3-取代羟吲哚的不对称磺酰基化反应。利用易得的N-苯硫基邻苯二甲酰亚胺作为硫源，在温和的反应条件下，以优异的产率和对映选择性合成了一系列光学活性的3-苯硫基吲哚.
Catalytic asymmetric sulfenylation of unprotected 3-substituted oxindoles has been developed via cooperative catalysis of a chiral N,N-dioxide-Sc(OTf)(3) complex and a Bronsted base. Utilizing readily available N-(phenylthio)phthalimide as the sulfur source, a wide range of optically active 3-phenylthiooxindoles were obtained in excellent yields with excellent enantioselectivities under mild reaction conditions.