Lymphomatoid papulosis and anaplastic large cell lymphomas of the skin
Lymphomatoid papulosis and anaplastic large cell lymphomas of the skin
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DOI：
10.1016/s1085-5629(00)80007-3
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发表时间：
2000-06-01
影响因子：
--
通讯作者：
Kadin, ME
中科院分区：
文献类型：
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作者：
Drews, R;Samel, A;Kadin, ME
现在普遍认为，原发性CD 30+皮肤淋巴瘤包括临床和形态学谱，其中淋巴瘤样丘疹病（LyP）和淋巴瘤之间的明确区分并不总是能够做出。自发缓解性疾病（如Lyp）涉及在疾病已经扩散到皮外部位的患者中进行或不进行自体干细胞移植的多药剂化疗方案，区域淋巴结（如播散性CD 30+淋巴瘤），选择适当的治疗策略需要将患者的临床病史（包括症状）与体格检查和病理结果相关联。临床病理学相关性的重要性不能过分强调，因为临床上“良性”行为的病变可能在病理学上表现为“恶性”，并且未能根据患者的临床病史和体格检查解释病理学结果可能导致不必要的，过度积极的和潜在的有害治疗。本文综述了这些原发性皮肤CD30+淋巴组织增生性疾病的临床和病理特征。Copyright（C）2000 by W.B.桑德斯公司
It is now generally accepted that primary CD30+ cutaneous lymphomas comprise a clinical and morphologic spectrum in which a clear distinction between lymphomatoid papulosis (LyP) and lymphoma cannot always be made, Management varies from observation in patients who have relatively asymptomatic, spontaneously remitting disease (as in LyP) to multiagent chemotherapy regimens with or without autologous stem cell transplantation in patients whose disease has spread to involve extracutaneous sites other than regional lymph nodes (as in disseminated CD30+ lymphoma), Choosing an appropriate management strategy requires correlation of the patient's clinical history (including symptoms) with physical exam and pathologic findings. The importance of clinicopathologic correlation cannot be overemphasized, because lesions with clinically "benign" behavior may appear "malignant" by pathology, and failure to interpret pathologic findings in accordance with the patient's clinical history and physical exam can result in unnecessary, overly aggressive, and potentially harmful treatments. This review highlights integration of clinical and pathologic features of these primary cutaneous CD30+ lymphoproliferative disorders. Copyright (C) 2000 by W.B. Saunders Company.