Mesenchymal stem cells and cardiac repair.
Mesenchymal stem cells and cardiac repair.
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间充质干细胞和心脏修复。
DOI：
10.1111/j.1582-4934.2008.00457.x
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发表时间：
2008-10
影响因子：
5.3
通讯作者：
Steinhoff G
中科院分区：
文献类型：
--
作者：
Nesselmann C;Ma N;Bieback K;Wagner W;Ho A;Konttinen YT;Zhang H;Hinescu ME;Steinhoff G
越来越多的临床和实验证据表明，间充质干细胞（MSC）是治疗心脏功能障碍的有前景的细胞类型。它们可能会触发修复性生长因子的产生，替换受损细胞并创造有利于内源性心脏修复的环境。然而，调节间充质干细胞在心脏修复中的作用的机制仍在研究中。为了实现最大的临床效益，离体操作可以进一步增强间充质干细胞的治疗潜力。本综述重点关注 MSC 在心脏修复中的机制，重点是离体操作。
Accumulating clinical and experimental evidence indicates that mesenchymal stem cells (MSCs) are promising cell types in the treatment of cardiac dysfunction. They may trigger production of reparative growth factors, replace damaged cells and create an environment that favours endogenous cardiac repair. However, identifying mechanisms which regulate the role of MSCs in cardiac repair is still at work. To achieve the maximal clinical benefits, ex vivo manipulation can further enhance MSC therapeutic potential. This review focuses on the mechanism of MSCs in cardiac repair, with emphasis on ex vivo manipulation.