Role of obesity in the risk of breast cancer: lessons from anthropometry.
Role of obesity in the risk of breast cancer: lessons from anthropometry.
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DOI：
10.1155/2013/906495
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发表时间：
2013
影响因子：
--
通讯作者：
Romieu I
中科院分区：
文献类型：
--
作者：
Amadou A;Hainaut P;Romieu I
据估计，全世界每年有138万新的乳腺癌病例被诊断出来。其中，大多数被归类为浸润性导管细胞癌。BC亚型通常分为5个“固有”亚型，即管腔A、管腔B、正常样、HER2阳性和基底样亚型。流行病学证据表明，人体测量因素与BC的发展有关。总体上，在绝经后女性中，高体重指数(BMI)和腰臀比(WHR)与BC风险之间存在一致的正相关关系，而对于绝经前BC，无论是BMI还是其他人体测量学参数以及跨种族群体，结果都是相互矛盾的。此外，一些证据表明，童年或青春期的体型、体型和体重增加可能在患BC的风险中发挥作用。本文就不同年龄的人体测量指标与BC风险之间的联系进行综述，以加深对体脂分布在BC风险中的作用的认识，并根据绝经状况和民族的不同来研究这些关联的差异，并探讨体型与BC风险之间的潜在生物学机制。
An estimated 1.38 million new cases of breast cancer (BC) are diagnosed each year in women worldwide. Of these, the majority are categorized as invasive ductal cell carcinoma. Subgroups of BC are frequently distinguished into five “intrinsic” subtypes, namely, luminal A, luminal B, normal-like, HER2-positive, and basal-like subtypes. Epidemiological evidence has shown that anthropometric factors are implicated in BC development. Overall consistent positive associations have been observed between high body mass index (BMI) and waist-to-hip ratio (WHR) and the risk of BC among postmenopausal women, while conflicting results persist for premenopausal BC, both for BMI and for other anthropometric parameters as well as across ethnic groups. Furthermore, some evidence suggests that body size, body shape, and weight gain during childhood or adolescence may play a role in the risk of BC. In this paper, we describe the evidence linking anthropometric indices at different ages and BC risk, in order to improve our understanding of the role of body fat distribution in the risk of BC, investigate differences in these associations according to menopausal status and ethnic groups, and discuss the potential biological mechanisms linking body size and BC risk.