Anthocyanin content, antioxidant, anti-inflammatory and anticancer properties of blackberry and raspberry fruits
Anthocyanin content, antioxidant, anti-inflammatory and anticancer properties of blackberry and raspberry fruits
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DOI：
10.1016/j.jfca.2009.08.012
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发表时间：
2010-09-01
影响因子：
4.3
通讯作者：
Nair, Muraleedharan G.
中科院分区：
文献类型：
--
作者：
Bowen-Forbes, Camille S.;Zhang, Yanjun;Nair, Muraleedharan G.
许多消费者认为新鲜或加工过的浆果对健康有益。密切相关的植物物种的果实有时具有显著不同的植物化学和生物活性。因此，尽管对许多红莓进行了类似的研究，但对以前没有研究过的物种的调查有很大的相关性。在目前的报告中，牙买加种植的三种野生物种的果实：牙买加树莓、玫瑰树莓和总状树莓，以及密歇根种植的尖叶树莓、点子树莓。遗产与鲁布斯思想5。测定其花青素含量，以及脂质过氧化、环氧合酶和人肿瘤细胞增殖抑制活性。结果表明，该果实的花青素含量（146 ~ 2199 mg/100 g鲜重）高于其他树莓和黑莓品种，其己烷、乙酸乙酯和甲醇提取物具有良好的抗氧化活性，大多数提取物在50 μ g/mL时具有50%以上的脂质过氧化抑制活性。在100 μ g/mL的浓度下，牙买加树属植物的己烷提取物表现出中等的COX抑制活性（27.5-33.1%），并表现出最大的抑制肿瘤细胞生长的潜力，对结肠癌、乳腺癌、肺癌和胃癌细胞的抑制率分别为50%、24%、54%和37%。这些水果的高花青素含量和生物活性表明，食用它们对健康有益，并且它们可能用于生产含有有效剂量花青素的功能食品。(C) 2009爱思唯尔公司版权所有。
Fresh or processed berries are considered to be beneficial for health by many consumers. Fruits of closely related species of plants sometimes possess strikingly different phytochemistry and biological activities. Therefore, even though similar research has been conducted on a number of Rubus berries, there is much relevance associated with the investigation of species that have not been previously studied. In the current report, the fruits of three wild Jamaica-grown species: Rubus jamaicensis, Rubus rosifolius and Rubus racemosus, and of the Michigan-grown Rubus acuminatus, Rubus idaeus cv. Heritage and Rubus idaeus cv. Golden were analyzed for their anthocyanin contents, and lipid peroxidation, cyclooxygenase enzyme and human tumor cell proliferation inhibitory activities. It was revealed that the fruits contained superior levels of anthocyanins (146-2199 mg/100 g fresh weight) to those previously reported for other raspberry and blackberry species, and their hexane, EtOAc and MeOH extracts showed good antioxidant activity, the majority of the extracts exhibiting over 50% lipid peroxidation inhibitory activity at 50 mu g/mL. The hexane extracts of the Jamaican Rubus spp. demonstrated moderate COX inhibitory activity (27.5-33.1%) at 100 mu g/mL, and exhibited the greatest potential to inhibit cancer cell growth, inhibiting colon, breast, lung, and gastric human tumor cells by 50, 24, 54 and 37%, respectively. The high anthocyanin content and biological activities of these fruits indicate that their consumption would be beneficial to health, and that they may be useful in the production of functional foods containing an efficacious dose of anthocyanins. (C) 2009 Elsevier Inc. All rights reserved.