A negative correlation between human carotid atherosclerotic plaque progression and plaque wall stress:: In vivo MRI-based 2D/3D FSI models
A negative correlation between human carotid atherosclerotic plaque progression and plaque wall stress:: In vivo MRI-based 2D/3D FSI models
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DOI：
10.1016/j.jbiomech.2007.11.026
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发表时间：
2008-01-01
影响因子：
2.4
通讯作者：
Yuan, Chun
中科院分区：
文献类型：
--
作者：
Tang, Dalin;Yang, Chun;Yuan, Chun
动脉粥样硬化的发生和发展与低的和振荡的流动壁切应力（FSS）正相关，这是公认的。然而，这一机制不能解释为什么晚期斑块在FSS升高的条件下继续生长。本文介绍了117个人体颈动脉粥样硬化斑块的基于磁共振成像（MRI）的2D/3D多组分模型（FSI，仅3D），以量化由壁厚增加（WTI）测量的斑块进展与斑块壁（结构）应力（PWS）条件之间的相关性。使用经组织学验证的多对比度MRI方案采集多年体内MRI图像。我们使用2D模型（200-700个数据点/患者）的结果表明，研究的21名患者中有18名在时间2（T2）时WTI和PWS之间显示出显著的负相关性。Pearson相关系数的95%置信区间为（-0.443，-0.246），p
It is well accepted that atherosclerosis initiation and progression correlate positively with low and oscillating flow wall shear stresses (FSS). However, this mechanism cannot explain why advanced plaques continue to grow under elevated FSS conditions. 117 vivo magnetic resonance imaging (MRI)-based 2D/3D multi-component models with fluid-structure interactions (FSI, 3D only) for human carotid atherosclerotic plaques were introduced to quantify correlations between plaque progression measured by wall thickness increase (WTI) and plaque wall (structure) stress (PWS) conditions. A histologically validated multi-contrast MRI protocol was used to acquire multi-year in vivo MRI images. Our results using 2D models (200-700 data points/patient) indicated that 18 out of 21 patients studied showed significant negative correlation between WTI and PWS at time 2 (T2). The 95% confidence interval for the Pearson correlation coefficient is (-0.443, -0.246), p