Light and Moderate Alcohol Consumption Significantly Reduces the Prevalence of Fatty Liver in the Japanese Male Population
Light and Moderate Alcohol Consumption Significantly Reduces the Prevalence of Fatty Liver in the Japanese Male Population
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DOI：
10.1038/ajg.2009.361
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发表时间：
2009-09-01
影响因子：
9.8
通讯作者：
Urabe, Akio
中科院分区：
文献类型：
--
作者：
Gunji, Toshiaki;Matsuhashi, Nobuyuki;Urabe, Akio
饮酒对肝脏的影响是有争议的。最近的报告表明，适量饮酒可降低丙氨酸氨基转移酶水平升高的患病率。然而，酒精消费在脂肪肝（FL）发展中的作用尚未得到明确研究。本研究的目的是探讨酒精消费和FL之间的关联在一个大的日本population.METHODS：共7,431无症状的男性受试者进行了完整的医学调查，在我们的研究所2007年5月和2008年7月之间被招募。排除了B或C型肝炎病毒阳性、潜在肝毒性药物摄入或正在接受代谢紊乱治疗的病例。超声检查确定FL。通过计算机断层扫描测量内脏和皮下脂肪组织（VAT和SAT）。与FL相关的独立和显著的预测因子通过多元Logistic回归分析确定。结果：在最初的研究候选人中，130例（1.7%）为B型肝炎阳性，66例（0.8%）为丙型肝炎阳性。根据纳入和排除标准，对5，599名男性（50.9 +/- 8.1岁）进行了横断面研究。光（40-140 g/周）和中度（140-280克/周）饮酒显著和独立地降低了FL的可能性（比值比= 0.824和0.754，95%置信区间= 0.683-0.994和0.612-0.928，P = 0.044和0.008，在调整潜在的混杂变量后，通过多变量分析。增值税，SAT，低密度脂蛋白，甘油三酯和空腹血糖是显着的预测因子FL的患病率增加，而年龄是一个预测因子的患病率下降的FL。结论：FL的患病率显着和独立地降低了轻度和中度饮酒的男性无症状的日本人口。
OBJECTIVES: The effect of alcohol consumption on the liver is controversial. Recent reports have suggested that moderate alcohol consumption decreases the prevalence of elevated alanine aminotransferase levels. The role of alcohol consumption in the development of fatty liver (FL), however, has not been studied definitively. The aim of this study was to examine the association between alcohol consumption and FL in a large Japanese population.METHODS: A total of 7,431 asymptomatic male subjects who underwent a complete medical survey in our institute between May 2007 and July 2008 were recruited. Cases positive for hepatitis B or C viruses, potential hepatotoxic drug intake, or under treatment for metabolic disorders were excluded. FL was defined by ultrasonography. Visceral and subcutaneous adipose tissues (VAT and SAT) were measured by computed tomography. Independent and significant predictors associated with FL were determined by multiple logistic regression analysis.RESULTS: Of the initial study candidates, 130 (1.7%) were positive for hepatitis B and 66 (0.8%) were positive for hepatitis C. On the basis of the inclusion and exclusion criteria, 5,599 men (50.9 +/- 8.1 years) were studied cross-sectionally. Light (40-140 g/week) and moderate (140-280 g/week) alcohol consumption significantly and independently reduced the likelihood of FL (odds ratio = 0.824 and 0.754, 95% confidence interval = 0.683-0.994 and 0.612-0.928, P = 0.044 and 0.008, respectively) by multivariate analysis after adjusting for potential confounding variables. VAT, SAT, low-density lipoprotein, triglycerides, and fasting blood glucose were significant predictors of the increased prevalence of FL, whereas age was a predictor of the decreased prevalence of FL.CONCLUSIONS: The prevalence of FL was significantly and independently decreased by light and moderate alcohol consumption in men of an asymptomatic Japanese population.