Translational selection of genes coding for perfectly conserved proteins among three mosquito vectors.
Translational selection of genes coding for perfectly conserved proteins among three mosquito vectors.
复制标题
三种蚊子载体中编码完美保守蛋白质的基因的翻译选择。
DOI：
10.1016/j.meegid.2012.06.005
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Behura,SusantaK
中科院分区：
文献类型：
--
作者：
Rodriguez,Olaf;Singh,BrajendraK;Severson,DavidW;Behura,SusantaK
同义密码子的偏向使用影响基因的翻译效率。我们研究了三种重要的蚊子媒介物种：埃及伊蚊（登革热病毒的载体），冈比亚按蚊（疟疾的载体）和致倦库蚊（淋巴丝虫病和西尼罗河病毒的载体）之间在氨基酸水平上完全保守的基因的密码子使用模式。虽然这些蛋白质具有相同的氨基酸序列，但同义密码子的非随机使用在直向同源基因中是明显的。模拟这些基因的编码序列以产生随机突变位点，以进一步研究密码子偏好的模式。结果发现，密码子使用偏好是显着更高的基因，代表完全保守的蛋白质比基因的变异是明显的氨基酸序列。我们的研究结果表明，编码完全保守的蛋白质的基因是高度偏向于优化的密码子，并可能在这些载体物种严格的翻译选择。
The biased usage of synonymous codons affects translational efficiency of genes. We studied codon usage patterns of genes that are perfectly conserved at the amino acid level among three important mosquito vector species: Aedes aegypti (vector of dengue virus), Anopheles gambiae (vector of malaria) and Culex quinquefasciatus (vector of lymphatic filariasis and West Nile Virus). Although these proteins have the same amino acid sequences, non-random usage of synonymous codons is evident among the orthologous genes. The coding sequences of these genes were simulated to generate random mutation sites to be further investigated for patterns of codon bias. It was found that codon usage bias is significantly higher in genes that represented perfectly conserved proteins than genes where variation was apparent at the amino acid sequence. Our results suggest that genes coding for perfectly conserved proteins are highly biased with optimized codons and may be under stringent translational selection in these vector species.
影响因子：
10.7
作者：
Tamura, Koichiro;Dudley, Joel;Kumar, Sudhir
通讯作者：
Kumar, Sudhir
影响因子：
10.7
作者：
Hall, Barry G.
通讯作者：
Hall, Barry G.
DOI：
10.1073/pnas.0307827100
发表时间：
2004-03-09
影响因子：
11.1
作者：
Chen, SL;Lee, W;McAdams, HH
通讯作者：
McAdams, HH