Social isolation and cardiovascular disease:: An atherosclerotic pathway?
Social isolation and cardiovascular disease:: An atherosclerotic pathway?
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DOI：
10.1016/s0306-4530(98)00061-4
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发表时间：
1998-11-01
影响因子：
3.7
通讯作者：
Uvnäs-Moberg, K
中科院分区：
文献类型：
--
作者：
Knox, SS;Uvnäs-Moberg, K
本文概述了社会支持可以影响心血管疾病预防或进展的两种途径：健康行为和神经内分泌机制。它的主要重点是神经内分泌途径，回顾了表明缺乏社会支持与冠状动脉病变发展的病因学相关的数据，其机制有两种：交感神经-肾上腺髓质对初始内皮损伤时血小板功能、心率和血压的影响；垂体-肾上腺皮质因子参与损伤后病变进展过程中平滑肌细胞增殖。它假设社会支持对心血管系统的缓冲作用主要是通过与催产素释放相关的机制介导的。1998爱思唯尔科学有限公司版权所有。
This paper outlines two pathways through which social support can influence the prevention or progression of cardiovascular disease: health behaviors and neuroendocrine mechanisms. Its primary focus is on neuroendocrine pathways, reviewing data which suggest that lack of social support is etiologically related to coronary artery lesion development through two mechanisms: sympathetic-adrenomedullary influences on platelet function, heart rate and blood pressure in the initial endothelial injury; and pituitary-adrenal cortical factors involved in smooth muscle cell proliferation during progression of the lesion after injury has taken place. It hypothesizes that the buffering effect of social support on the cardiovascular system is mediated primarily through mechanisms associated with the release of oxytocin. (C) 1998 Elsevier Science Ltd. All rights reserved.