[Intestinal absorption and renal excretion mediated by transporters and the relationship with drug-drug interaction].
[Intestinal absorption and renal excretion mediated by transporters and the relationship with drug-drug interaction].
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转运蛋白介导的肠吸收和肾排泄及其与药物相互作用的关系[J].
DOI：
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
Ke
中科院分区：
文献类型：
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作者：
Jian Zhang;Ke
药物间相互作用（Drug-drug interaction，DDI）是指药物同时或连续给药时，药物的理化性质以及药代动力学或药效学的变化。药物相互作用的临床结果可分为良好的临床疗效和不良相互作用。随着药物种类的逐年增加，新的耐药性也不断出现。这一现象使得联合用药增多，从而使药物相互作用，特别是不良相互作用出现。体内药物相互作用的机制与许多因素有关，包括药物代谢酶系统和膜转运蛋白。近年来的研究表明，转运蛋白在药物的吸收、分布、代谢和消除过程中发挥着重要作用。为了避免转运蛋白介导的严重副作用，促进临床合理用药，本文综述了转运蛋白介导的肠道吸收和肾脏排泄机制。
Drug-drug interaction (DDI) is referred as the changes of physical and chemical properties, as well as the pharmacokinetics or pharmacodynamics of drugs administered simultaneously or consecutively. The clinical results for drug-drug interaction could be divided into good clinical efficacy and adverse interaction. With the kinds of drugs increasing every year, new drug resistances spring up frequently. This phenomenon makes drug combination increased so that the drug interaction, especially the adverse interaction emerged. The mechanisms of in vivo drug-drug interaction are relevant to a number of factors, including drug-metabolizing enzyme systems and membrane transporters. Recent studies have revealed the important role played by transporters in drug absorption, distribution, metabolism and elimination. In order to avoid severe side effects mediated by transporters and to promote rational combination in clinics, the mechanisms of intestinal absorption and renal excretion mediated by transporters are reviewed.