The impact of pathological high-frequency oscillations on hippocampal network activity in rats with chronic epilepsy
The impact of pathological high-frequency oscillations on hippocampal network activity in rats with chronic epilepsy
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DOI：
10.7554/elife.42148
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发表时间：
2019-02-22
期刊：
影响因子：
7.7
通讯作者：
Leutgeb, Jill K.
中科院分区：
文献类型：
--
作者：
Ewell, Laura A.;Fischer, Kyle B.;Leutgeb, Jill K.
在癫痫中，大脑网络在发作间期产生病理性高频振荡（pHFO）。为了了解pHFOs如何不同于重叠频带中的正常振荡并可能干扰海马处理，我们对有和无慢性癫痫的行为大鼠进行了高密度单单位和局部场电位记录。在癫痫动物中，我们观察到两种类型的共同发生的快速振荡，与对照动物相比，我们可以将其归类为“波纹状”或“pHFO”。我们比较了他们的光谱特征，大脑状态依赖性和细胞参与者。引人注目的是，pHFO的发生与大脑状态无关，与发作间期尖峰相关，与涟漪样事件相比，主要神经元的不同子网络参与，增加了网络活动的稀疏性，并启动了空间信息编码的一般和立即中断。综上所述，我们的研究结果表明，导致pHFO的事件对记忆过程有直接影响，证实了对pHFO进行适当分类的必要性，以促进选择性靶向病理活动的治疗干预。
In epilepsy, brain networks generate pathological high-frequency oscillations (pHFOs) during interictal periods. To understand how pHFOs differ from normal oscillations in overlapping frequency bands and potentially perturb hippocampal processing, we performed high-density single unit and local field potential recordings from hippocampi of behaving rats with and without chronic epilepsy. In epileptic animals, we observed two types of co-occurring fast oscillations, which by comparison to control animals we could classify as 'ripple-like' or 'pHFO'. We compared their spectral characteristics, brain state dependence, and cellular participants. Strikingly, pHFO occurred irrespective of brain state, were associated with interictal spikes, engaged distinct subnetworks of principal neurons compared to ripple-like events, increased the sparsity of network activity, and initiated both general and immediate disruptions in spatial information coding. Taken together, our findings suggest that events that result in pHFOs have an immediate impact on memory processes, corroborating the need for proper classification of pHFOs to facilitate therapeutic interventions that selectively target pathological activity.