Functional Imaging of Audio-Visual Selective Attention in Monkeys and Humans: How do Lapses in Monkey Performance Affect Cross-Species Correspondences?
Functional Imaging of Audio-Visual Selective Attention in Monkeys and Humans: How do Lapses in Monkey Performance Affect Cross-Species Correspondences?
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DOI：
10.1093/cercor/bhx092
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发表时间：
2017-06-01
期刊：
影响因子：
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通讯作者：
Petkov CI
中科院分区：
文献类型：
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作者：
Rinne T;Muers RS;Salo E;Slater H;Petkov CI
在人类和动物模型中，注意力如何调节大脑反应的跨物种对应和差异知之甚少。我们训练两只猴子在功能磁共振成像(FMRI)过程中执行视听选择性注意任务，奖励它们注意一种模式的刺激，而忽略另一种模式的刺激。猴子fMRI确定了强烈受听觉或视觉注意调制的区域。令人惊讶的是，在功能磁共振成像过程中，与听觉注意相关的调节在猴子身上要比执行相同任务的人类受到更多的限制。进一步的分析排除了微不足道的解释，表明不稳定的选择性注意表现与猴子广泛皮质区域的不均匀调制有关。这些发现为视听选择性注意如何调节灵长类动物的大脑提供了初步的见解，找出了猴子“丢失”注意力效应的来源，并对建立人类与非人类动物认知的神经生物学模型提供了启示。
The cross-species correspondences and differences in how attention modulates brain responses in humans and animal models are poorly understood. We trained 2 monkeys to perform an audio–visual selective attention task during functional magnetic resonance imaging (fMRI), rewarding them to attend to stimuli in one modality while ignoring those in the other. Monkey fMRI identified regions strongly modulated by auditory or visual attention. Surprisingly, auditory attention-related modulations were much more restricted in monkeys than humans performing the same tasks during fMRI. Further analyses ruled out trivial explanations, suggesting that labile selective-attention performance was associated with inhomogeneous modulations in wide cortical regions in the monkeys. The findings provide initial insights into how audio–visual selective attention modulates the primate brain, identify sources for “lost” attention effects in monkeys, and carry implications for modeling the neurobiology of human cognition with nonhuman animals.