Risk factors for the development of hyperuricemia A STROBE-compliant cross-sectional and longitudinal study
Risk factors for the development of hyperuricemia A STROBE-compliant cross-sectional and longitudinal study
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DOI：
10.1097/md.0000000000017597
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发表时间：
2019-10-01
期刊：
影响因子：
1.6
通讯作者：
Zhang, Renbing
中科院分区：
文献类型：
--
作者：
Ni, Qun;Lu, Xiaomin;Zhang, Renbing
高尿酸血症作为一个重大的公共卫生问题越来越受到人们的重视。本研究旨在探讨高尿酸血症的危险因素及生化指标变化与高尿酸血症发生的关系。基线水平无高尿酸血症的参与者接受为期6年的年度随访检查。COX比例风险回归分析用于计算发生高尿酸血症的风险。在9238名参与者中，1704人(18.4%)被诊断为高尿酸血症。在21,757人年的随访中，确认了1492例高尿酸血症病例。所有受试者的高尿酸血症发生率为每1000人年68.58例。高尿酸血症的患病率和发病率在50岁以上的女性中显著增加。体重指数、SBP、空腹血糖、甘油三酯、低密度脂蛋白胆固醇、丙氨酸氨基转移酶、尿素氮和肌酐的高水平增加了高尿酸血症的风险。患脂肪肝还会增加患高尿酸血症的风险。研究发现，舒张压(DBP)、血清甘油三酯(TG)、尿素氮(BUN)、肌酐和高密度脂蛋白胆固醇(HDLC)水平的变化与高尿酸血症的发生独立相关。
Hyperuricemia has received increasing attention as a major public health problem. This study aims to investigate the risk factors for hyperuricemia and to explore the relationship between changes in biochemical variables and incident hyperuricemia.A cross-sectional and subsequently prospective study was performed among adults who took their health checkups at Zhejiang University Hospital. The participants who were free of hyperuricemia at baseline received annual follow-up examinations during a 6-year period. Cox proportional hazards regression analyses were conducted to calculate the risks for incident hyperuricemia.Of the 9238 participants enrolled, 1704 (18.4%) were diagnosed as hyperuricemia. During 21,757 person-years of follow-up, 1492 incident hyperuricemia cases were identified. The incidence of hyperuricemia was 68.58 cases per 1000 person-year of follow-up in the overall participants. The prevalence and the incidence of hyperuricemia increased greatly in female older than 50 years. High levels of BMI, SBP, FPG, TG, LDL-C, ALT, BUN, and creatinine increased the risk of hyperuricemia. Suffering fatty liver also increased the risk of hyperuricemia. Subjects with increasing DBP, TG, BUN, creatinine, or decreasing HDL-C were more likely to incident hyperuricemia.This study revealed that the change of diastolic blood pressure (DBP), serum triglycerides (TG), blood urea nitrogen (BUN), creatinine, and high-density lipoprotein cholesterol (HDL-C) level were independently associated with incident hyperuricemia.