A defined network of fast-spiking interneurons in orbitofrontal cortex: responses to behavioral contingencies and ketamine administration
A defined network of fast-spiking interneurons in orbitofrontal cortex: responses to behavioral contingencies and ketamine administration
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DOI：
10.3389/neuro.06.013.2009
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发表时间：
2009-01-01
影响因子：
3
通讯作者：
Mainen, Zachary F.
中科院分区：
文献类型：
--
作者：
Quirk, Michael C.;Sosulski, Dara L.;Mainen, Zachary F.
眼窝额叶皮层（OFC）是前额叶皮层的一个区域，与行为的动机控制和精神病和抑郁症的相关异常有关。据推测，这些疾病的一个关键机制是正常调节前额叶信息处理的gaba能中间神经元功能障碍。在这里，我们用细胞外波形和尖峰序列分析研究了大鼠OFC中分离的一个中间神经元亚类。在执行目标导向的行为任务时，这类假定的快速尖峰（FS）中间神经元的放电显示出强大的时间相关性，表明功能连贯的网络。FS细胞活性还与行为反应潜伏期（动机状态的关键指标）共变。全身服用氯胺酮，一种可以模拟精神病的药物，会优先抑制这类细胞。总之，这些结果支持了OFC-FS中间神经元在正常和异常大脑和行为状态下通过前额叶回路调节动机的关键环节。
Orbitofrontal cortex (OFC) is a region of prefrontal cortex implicated in the motivational control of behavior and in related abnormalities seen in psychosis and depression. It has been hypothesized that a critical mechanism in these disorders is the dysfunction of GABAergic interneurons that normally regulate prefrontal information processing. Here, we studied a subclass of interneurons isolated in rat OFC using extracellular waveform and spike train analysis. During performance of a goal-directed behavioral task, the firing of this class of putative fast-spiking (FS) interneurons showed robust temporal correlations indicative of a functionally coherent network. FS cell activity also co-varied with behavioral response latency, a key indicator of motivational state. Systemic administration of ketamine, a drug that can mimic psychosis, preferentially inhibited this cell class. Together, these results support the idea that OFC-FS interneurons form a critical link in the regulation of motivation by prefrontal circuits during normal and abnormal brain and behavioral states.