Co-Infection of Cattle with Fasciola hepatica and Mycobacterium bovis - Immunological Consequences
Co-Infection of Cattle with Fasciola hepatica and Mycobacterium bovis - Immunological Consequences
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DOI：
10.1111/j.1865-1682.2009.01075.x
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发表时间：
2009-08-01
影响因子：
4.3
通讯作者：
McNair, J.
中科院分区：
文献类型：
--
作者：
Flynn, R. J.;Mulcahy, G.;McNair, J.
肝片形吸虫是一种常见的寄生在世界上许多地方的牛身上的寄生虫.以前，我们已经表明，牛感染F。肝细胞对M的反应性（迟发型超敏反应和细胞因子反应）改变。牛卡介苗感染。我们假设，与F。同样地，Hepatica也会改变牛对强毒M.牛感染，可能对疾病诊断和疾病进展产生影响。我们以前的工作与F。hepatica/M. bovis BCG感染的牛在共感染的动物中表现出干扰素（IFN）-γ应答性的降低。类似的发现在这里报道的毒性M。牛气溶胶感染后。这些发现的流行病学意义，也需要探索，特别是考虑到相当多的资源用于诊断和根除牛结核病，以及F。在难以根除的地区，
P>Fasciola hepatica, the liver fluke, is a common parasite of cattle in much of the world. Previously, we have shown that cattle infected with F. hepatica have altered responsiveness (delayed type hypersensitivity reaction and cytokine responses) to M. bovis BCG infection. We hypothesized that co-infection with F. hepatica would, likewise, alter the immune response of cattle to virulent M. bovis infection, with possible implications for disease diagnosis and disease progression. Our previous work with F. hepatica/M. bovis BCG-infected cattle demonstrated a reduction in interferon (IFN)-gamma responsiveness in co-infected animals. Similar findings are reported here with virulent M. bovis following aerosol infection. The epidemiological significance of these findings, also, require exploration, particularly in view of the considerable resources devoted to the diagnosis and eradication of bovine tuberculosis, and the high prevalence of F. hepatica infection in areas where eradication has proved difficult.