Transcranial direct current stimulation over the right dorsolateral prefrontal cortex has distinct effects on choices involving risk and ambiguity.
Transcranial direct current stimulation over the right dorsolateral prefrontal cortex has distinct effects on choices involving risk and ambiguity.
复制标题
对右侧背外侧前额叶皮层的经颅直流电刺激对涉及风险和模糊性的选择具有明显的影响。
DOI：
10.1016/j.bbr.2020.113044
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发表时间：
2020
影响因子：
2.7
通讯作者：
Zhang Hanqi
中科院分区：
文献类型：
--
作者：
Xiong Guanxing;She Zhe;Zhao Jun;Zhang Hanqi
人类的不确定性决策涉及风险（概率已知）和模糊性（概率未知）的选择。对于风险和模糊的决策过程，神经差异很少表现出来。为了阐明右背外侧前额叶皮层（DLPFC）在不确定情况下的因果作用，我们使用经颅直流电刺激（tDCS）来证明右DLPFC参与涉及风险和模糊性的决策。参与者在右侧DLPFC上接受1.5 mA的阳极或阴极tDCS或假刺激，随后进行风险和模糊性任务。结果表明，通过阳极刺激，个体对模糊性的偏好可以显著增加，但在群体之间对风险选择的偏好没有显著差异。这些发现表明，不同的神经机制是危险和模糊决策的基础，因为正确的DLPFC主要影响模糊行为。
Human’s uncertain decision-making involves choices of risk (with known probabilities) and ambiguity (with unknown probabilities). For risky and ambiguous decision-making processes, neural differences are rarely exhibited. To clarify the causal role of the right dorsolateral prefrontal cortex (DLPFC) in uncertain situations, we used transcranial direct current stimulation (tDCS) to demonstrate the involvement of the right DLPFC in decisions involving risk and ambiguity. Participants received either anodal or cathodal tDCS at 1.5 mA or sham stimulation over the right DLPFC and subsequently undertook tasks of risk and ambiguity. The results revealed that a preference for ambiguity could be measurably increased in individuals through anodal stimulation, but no significant differences were observed in the preferences for risky choices among groups. These findings suggest that different neural mechanisms underlie risky and ambiguous decisions because the right DLPFC primarily affects ambiguous behavior.