Assessment of Polymer/Bioactive Glass-Composite Microporous Spheres for Tissue Regeneration Applications
Assessment of Polymer/Bioactive Glass-Composite Microporous Spheres for Tissue Regeneration Applications
复制标题
DOI：
10.1089/ten.tea.2008.0203
复制
发表时间：
2009-07-01
影响因子：
4.1
通讯作者：
Day, Richard M.
中科院分区：
文献类型：
--
作者：
Keshaw, Hussila;Georgiou, George;Day, Richard M.
Conformable scaffold materials capable of rapid vascularization and tissue infiltration would be of value in the therapy of inaccessible wounds. Microporous spheres of poly(D,L-lactide-co-glycolide) (PLGA) containing bioactive glass (BG) were prepared using a thermally induced phase separation (TIPS) technique, and the bioactivity, in vitro degradation, and tissue integration of the microporous spheres were assessed. Microporous spheres containing 10% (w/w) BG stimulated a significant increase in vascular endothelial growth factor secretion from myofibroblasts consistently over a 10-day period (p
