TRP channels as sensors of oxygen availability
TRP channels as sensors of oxygen availability
复制标题
DOI：
10.1007/s00424-013-1237-9
复制
发表时间：
2013-02
期刊：
影响因子：
--
通讯作者：
T. Numata;Nozomi Ogawa;N. Takahashi;Y. Mori
中科院分区：
文献类型：
--
作者：
T. Numata;Nozomi Ogawa;N. Takahashi;Y. Mori
适应氧气供应变化的能力对于原核生物和真核生物的生存都是必不可少的。最近，由瞬时受体电位（trp）基因超家族编码的阳离子通道被认为是细胞内和细胞外环境中多种因素的多模态传感器，也是由Ca2+等离子介导的电信号和化学信号的换能器。TRP通道的功能特征使身体能够对不同形式的环境变化做出反应和适应，包括氧水平。TRP通道的一个亚类调节各种细胞过程以响应氧的波动。在这篇文章中，我们通过对比氧敏感TRP通道与其他离子通道、转运体和酶的氧监测功能，描述了氧敏感TRP通道的生理和病理意义，这些通道在细胞对急性氧变化的反应中是异质的。我们还讨论了氧敏感TRP通道作为药物治疗新一类靶蛋白的生理相关性。
An ability to adapt to changes in oxygen availability is essential for survival in both prokaryotic and eukaryotic organisms. Recently, cation channels encoded by thetransient receptor potential (trp)gene superfamily have been recognized as multimodal sensors of a wide variety of factors inside the cells and in the extracellular environment and also as transducers of electrical and chemical signals mediated by ions such as Ca2+. The functional features of TRP channels enable the body to react and adapt to different forms of environmental changes, including oxygen levels. A subclass of TRP channels regulates various cellular processes in response to fluctuations in oxygen. In this article, we describe the physiological and pathological significance of the oxygen-sensitive TRP channels, which are heterogeneous in the cellular responses to acute changes in oxygen, by contrasting their oxygen monitoring function with that of other ion channels, transporters, and enzymes. We also discuss the physiological relevance of oxygen-sensitive TRP channels as a novel class of target proteins for pharmaceutical therapeutics.