KINDLING WITH LOW-FREQUENCY STIMULATION - GENERALITY, TRANSFER, AND RECRUITING EFFECTS
KINDLING WITH LOW-FREQUENCY STIMULATION - GENERALITY, TRANSFER, AND RECRUITING EFFECTS
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DOI：
10.1016/0014-4886(81)90057-1
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发表时间：
1981-01-01
影响因子：
5.3
通讯作者：
CORCORAN, ME
中科院分区：
文献类型：
--
作者：
CAIN, DP;CORCORAN, ME
用低频方波脉冲刺激大鼠杏仁核、海马背侧和腹侧、梨状皮质和视前区，强度逐渐增加，直到全面性癫痫发作。3.0 Hz的刺激对所有研究结构的全面性癫痫发作都是有效的。当刺激频率在0.875 ~ 10.0 Hz之间时，受试者的扁桃体迅速点燃，并表现出向对侧扁桃体的快速转移。一些实验对象在一次试验中就点燃了。在0.875 ~ 10.0 Hz的频率刺激下，强烈的招募发生，并且总是先于点燃性癫痫发作的发生。低频刺激明显比高频刺激更有效地诱导前脑不同部位的癫痫发作。
Rats were stimulated in the amygdala, dorsal and ventral hippocampus, pyriform cortex and preoptic area with low-frequency square-wave pulses at gradually increasing intensities until a generalized seizure occurred. Stimulation at 3.0 Hz was effective for rapidly kindling generalized seizures in all structures studied. Subjects stimulated in the amygdala with frequencies of stimulation between 0.875 and 10.0 Hz kindled rapidly and exhibited rapid transfer to the contralateral amygdala. Some subjects kindled in 1 trial. Strong recruiting occurred in response to stimulation at frequencies between 0.875 and 10.0 Hz and invariably preceded the development of kindled seizures. Low-frequency stimulation evidently is more effective than high-frequency stimulation in inducing seizure development in a variety of forebrain sites.