Severe Anemia Is Associated with Systemic Inflammation in Young Children Presenting to a Tertiary Hospital in Uganda.
Severe Anemia Is Associated with Systemic Inflammation in Young Children Presenting to a Tertiary Hospital in Uganda.
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DOI：
10.4269/ajtmh.20-0199
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
John CC
中科院分区：
文献类型：
--
作者：
Opoka RO;Conroy AL;Waiswa A;Wasswa R;Tumwine JK;Karamagi C;John CC
炎症在非洲儿童严重贫血（SA）中的作用尚未得到很好的表征。我们进行了一项研究，以评估在乌干达的第三单位接纳的幼儿SA的危险因素。在乌干达金贾医院对5岁以下儿童的贫血的临床、感染和微量营养素风险因素沿着炎症标志物进行了评估。参与者包括284名患有SA（血红蛋白[Hb] < 5.0 g/dL）的儿童，以及两个对照组：63名患有急性疾病而没有SA（Hb > 9.3 g/dL）的儿童和53名无症状的社区对照儿童。进行适当的逻辑分析，以确定与SA相关的因素。在284名SA儿童中，36.5%患有恶性疟原虫寄生虫血症，32.7%患有黑水热（严重疟疾的一种），15.5%患有维生素B12缺乏症。HIV感染、菌血症、钩虫感染、严重急性营养不良和叶酸缺乏症相对少见（各占< 8%）。与合并对照组相比，与SA独立相关的因素包括（校正比值比[OR]; 95% CI）：恶性疟原虫寄生虫血症（OR：4.3; 95% CI：1.4-13.8），总白色血细胞计数（OR：1.3; 95%CI：1.1-1.4）、C-反应蛋白（OR：1.8; 95%CI：1.3-2.4）和铁蛋白（OR：2.7; 95%CI：1.9-4.0）。在乌干达的这一地区，疟疾和炎症标志物与儿童SA独立相关。需要进一步的研究来确定炎症在该人群中SA儿童中的作用。
The role of inflammation in severe anemia (SA) in African children has not been well characterized. We conducted a study to evaluate risk factors for SA in young children admitted at a tertiary unit in Uganda. Clinical, infectious, and micronutrient risk factors for anemia, along with markers of inflammation, were evaluated in children aged < 5 years in Jinja Hospital, Uganda. Participants included 284 children with SA (Hemoglobin [Hb] < 5.0 g/dL), and two control groups: 63 children admitted with acute illness without SA (Hb > 9.3 g/dL) and 53 asymptomatic community control children. Appropriate logistic analysis was performed to determine factors associated with SA. Of the 284 children with SA, 36.5% had Plasmodium falciparum parasitemia, 32.7% had blackwater fever (one of the types of severe malaria), and 15.5% had vitamin B12 deficiency. HIV infection, bacteremia, hookworm infection, severe acute malnutrition, and folate deficiency were relatively uncommon (each accounting for < 8%). Factors independently associated with SA compared with the combined control groups included (adjusted odds ratio [OR]; 95% CI) the following: P. falciparum parasitemia (OR: 4.3; 95% CI: 1.4–13.8), total white blood count (OR: 1.3; 95% CI: 1.1–1.4), C-reactive protein (OR: 1.8; 95% CI: 1.3–2.4), and ferritin (OR: 2.7; 95% CI: 1.9–4.0). In this area of Uganda, malaria and markers of inflammation were independently associated with SA in children. Additional studies are required to determine the role of inflammation in children with SA in this population.
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影响因子：
3.8
作者：
Manning L;Laman M;Rosanas-Urgell A;Michon P;Aipit S;Bona C;Siba P;Mueller I;Davis TM
通讯作者：
Davis TM
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