Asymmetric 1,3-dipolar cycloaddition reaction of azomethine imines to allyl alcohol
Asymmetric 1,3-dipolar cycloaddition reaction of azomethine imines to allyl alcohol
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DOI：
10.1246/cl.2008.342
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发表时间：
2008-03-05
影响因子：
1.6
通讯作者：
Inomata, Katsuhiko
中科院分区：
文献类型：
--
作者：
Kato, Tomomitsu;Fujinami, Shuhei;Inomata, Katsuhiko
以(R，R)-酒石酸二异丙酯为手性助剂，实现了甲亚胺与烯丙醇的不对称1，3-偶极环加成反应，得到了具有良好的区域选择性、非对映选择性和对映体选择性的光学活性反式吡唑烷类化合物。
The asymmetric 1,3-dipolar cycloaddition of azomethine imines to allyl alcohol was achieved by utilizing diisopropyl (R,R)-tartrate as a chiral auxiliary to afford the corresponding optically active trans-pyrazolidines with excellent regio-, diastereo-, and enantioselectivities.