Robust inflammatory and fibrotic signaling following volumetric muscle loss: a barrier to muscle regeneration.
Robust inflammatory and fibrotic signaling following volumetric muscle loss: a barrier to muscle regeneration.
复制标题
DOI：
10.1038/s41419-018-0455-7
复制
发表时间：
2018-03-14
影响因子：
9
通讯作者：
Aguilar CA
中科院分区：
文献类型：
--
作者：
Larouche J;Greising SM;Corona BT;Aguilar CA
骨骼肌具有非凡的再生能力，这是由一群被称为卫星细胞的常驻干细胞所赋予的。损伤后，卫星细胞增殖，分化，融合形成新的或修复现有的多核肌纤维。然而，在手术或创伤性肌肉临界质量损失（也称为体积肌肉损失1（VML））后，这种内源性再生能力被淹没。相反，VML已被证明可诱导强烈的瘢痕沉积、纤维化替代、功能丧失和严重的发病率2。这些结果被认为是由于除结缔组织和基底膜之外的常驻再生祖细胞的消融导致的，其提供结构、生化和机械线索以引导再生3。旨在恢复这些元素的再生疗法，例如来自未受伤部位的自体组织或干细胞转移3，或招募和引导修复细胞的指导性支架4的植入，已经产生了肌肉体积，力量，VML的成功再生疗法的发展受到对驱动和介导VML的分子现象的不完全理解的阻碍。损伤修复在本期《细胞死亡与发现》中，阿吉拉尔等人5通过使用多尺度方法表征对VML的病理生理反应，并将这些结果与再生治疗（切碎的肌肉移植物-MMG）的手术植入进行对比，从而解决了这一问题。研究人员使用肌肉功能测试、组织学和基因表达追踪了VML后56天的分子现象学
Skeletal muscle has a remarkable regenerative capacity, which is conferred by a pool of resident stem cells, known as satellite cells. After damage, satellite cells proliferate, differentiate, and fuse to form new or repair existing multinucleated myofibers. However, after surgical or traumatic loss of a critical mass of muscle, also known as volumetric muscle loss 1 (VML), this endogenous regenerative competence is overwhelmed. Rather VML has been shown to induce robust scar deposition, fibrotic supplantation, loss of function, and serious morbidity 2. These outcomes have been postulated to result from the ablation of resident regenerative progenitors in addition to connective tissue and basement membrane, which provide structural, biochemical, and mechanical cues to guide regeneration 3. Regenerative therapies that aim to restore these elements, such as autologous tissue or stem cell transfer 3 from an uninjured site, or implantation of an instructive scaffold 4 that recruits and guides reparative cells, have yielded incomplete recovery of muscle volume, strength, and function.The development of successful regenerative therapies for VML has been hindered by an incomplete understanding of the molecular phenomena driving and mediating injury repair. In this issue of Cell Death and Discovery, Aguilar et al. 5 addresses this issue by characterizing the pathophysiologic response to VML using a multi-scale approach, and contrasting those results to surgical implantation of a regenerative therapy (minced muscle grafts-MMGs). The investigators tracked the molecular phenomenology after VML over 56 days using muscle function testing, histology, and gene expression
登录
查看更多内容
影响因子：
15.9
作者：
Parker, Matthew W.;Rossi, Daniel;Bitterman, Peter B.
通讯作者：
Bitterman, Peter B.
影响因子：
4.6
作者：
Aguilar, Carlos A.;Shcherbina, Anna;Meissner, Alexander
通讯作者：
Meissner, Alexander
影响因子：
2.7
作者：
Corona, Benjamin T.;Wenke, Joseph C.;Ward, Catherine L.
通讯作者：
Ward, Catherine L.
影响因子：
7
作者：
Aguilar CA;Greising SM;Watts A;Goldman SM;Peragallo C;Zook C;Larouche J;Corona BT
通讯作者：
Corona BT
DOI：
10.5435/00124635-201102001-00007
发表时间：
2011-01-01
影响因子：
3.2
作者：
Grogan, Brian F.;Hsu, Joseph R.
通讯作者：
Hsu, Joseph R.