Coordinate Control of Retinal Neovascularization
Coordinate Control of Retinal Neovascularization
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视网膜新生血管的协调控制
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
R. J. Mello
中科院分区：
文献类型：
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作者：
R. J. Mello
血管生成是指新血管的发育。这种发展可以作为对正常生理事件或异常病理状况的反应而发生。正常血管生成过程的例子包括胚胎发生过程中发生的血管发育（Sabin，1920；Wagner，1980）和伤口愈合（Clark 和 Clark，1932；Cliff，1963；Schoefl，1963）。胚胎发生过程中发生的精确控制的血管化对于胎儿的正常发育至关重要，不仅在快速发育的组织内提供营养和废物交换，而且可能影响周围组织的发育（Goudie et al., 1980）。胚胎学家利用组织学技术记录了胚胎中胚层细胞向血岛和成血管细胞的转化（Sabin, 1920；Wagner, 1980）。形成新血管的能力不会随着胚胎发生的停止而丧失。事实上，如果受到适当刺激的影响，可以在大多数胚胎后血管化组织中诱导血管生成反应。例如，在伤口愈合过程中，受损组织（包括血管组织）会被修复或替换（Cliff，1963；Schoefl，1963）。
Angiogenesis refers to the development of new blood vessels. Such a development can occur as a response to either normal physiological events or abnormal pathological conditions. Examples of normal angiogenic processes include the vascular development which occurs during embryogenesis (Sabin, 1920; Wagner, 1980) and wound healing (Clark and Clark, 1932; Cliff, 1963; Schoefl, 1963). The precisely controlled vascularization which occurs during embryogenesis is crucial to proper fetal development, not only in providing for nutrient and waste exchange within rapidly developing tissues, but also, perhaps, in influencing the development of surrounding tissues (Goudie et al., 1980) Using histological techniques, embryologists have documented the transformation of embryonic mesodermal cells into blood islands and angioblasts (Sabin, 1920; Wagner, 1980). The ability to form new vessels is not lost with the cessation of embryogenesis. Indeed, if influenced by an appropriate stimulus, an angiogenic response can be induced in most post-embryonic vascularized tissues. During the process of wound healing, for example, damaged tissue, including vascular tissue, is either repaired or replaced (Cliff, 1963; Schoefl, 1963).