Larval competition alters susceptibility of adult Aedes mosquitoes to dengue infection
Larval competition alters susceptibility of adult Aedes mosquitoes to dengue infection
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DOI：
10.1098/rspb.2007.1497
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发表时间：
2008-02-22
影响因子：
4.7
通讯作者：
Reiskind, Michael H.
中科院分区：
文献类型：
--
作者：
Alto, Barry W.;Lounibos, L. Philip;Reiskind, Michael H.
登革热是最重要的人类虫媒病毒疾病，主要由埃及伊蚊传播，其次由白纹伊蚊传播。目前这些入侵物种的分布重叠，并受到种间幼虫在其容器栖息地的竞争。在这里，我们报告说，竞争也提高了登革热感染和传播率在这两个载体物种之一。我们确定了竞争对A.埃及伊蚊A.白纹伊蚊，比较它们对东南亚登革热病毒2型感染的敏感性。幼虫之间的高水平种内或种间竞争增强了A.白纹伊蚊对登革病毒感染的敏感性和传播潜力，表现为播散性感染。竞争幼虫的数量增加一倍（A。albopictus或A. aegypti），导致A.白纹伊蚊伴播散性登革热2型感染。竞争增强的载体能力似乎是由于减少了病毒感染和传播的“障碍”（形态学或生理学），可能有助于A。白纹伊蚊在登革热传播中的作用其他无关虫媒病毒的类似结果表明，在估计感染人类的病原体的载体能力时，应考虑蚊子中常见的幼虫竞争。
Dengue, the most important human arboviral disease, is transmitted primarily by Aedes aegypti and, to a lesser extent, by Aedes albopictus. The current distributions of these invasive species overlap and are affected by interspecific larval competition in their container habitats. Here we report that competition also enhances dengue infection and dissemination rates in one of these two vector species. We determined the effects of competition on adult A. aegypti and A. albopictus, comparing their susceptibility to infection with a Southeast Asian strain of dengue-2 virus. High levels of intra- or interspecific competition among larvae enhanced the susceptibility of A. albopictus to dengue virus infection and potential for transmission, as indicated by disseminated infections. Doubling the number of competing larvae (A. albopictus or A. aegypti), led to a significant (more than 60%) increase in the proportion of A. albopictus with disseminated dengue-2 infection. Competition-enhanced vector competence appears to result from a reduction in 'barriers' (morphological or physiological) to virus infection and dissemination and may contribute to the importance of A. albopictus in dengue transmission. Similar results for other unrelated arboviruses suggest that larval competition, common in mosquitoes, should be considered in estimates of vector competence for pathogens that infect humans.