In vitro development of resistance to six and four fluoroquinolones in Mycoplasma pneumoniae and Mycoplasma hominis, respectively
In vitro development of resistance to six and four fluoroquinolones in Mycoplasma pneumoniae and Mycoplasma hominis, respectively
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DOI：
10.1128/aac.49.3.1190-1193.2005
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发表时间：
2005-03-01
影响因子：
4.9
通讯作者：
Bébéar, CM
中科院分区：
文献类型：
--
作者：
Gruson, D;Pereyre, S;Bébéar, CM
分别针对肺炎支原体和人型支原体的一种参考菌株，研究了使用浓度递增的六种和四种不同氟喹诺酮类药物在连续传代培养中的耐药突变体选择。所有测试的氟喹诺酮类药物都选择了耐药性，其改变影响了四个靶拓扑异构酶基因的喹诺酮类耐药性决定区域。
Selection of resistant mutants in sequential subcultures with increasing concentrations of six and four different fluoroquinolones was studied for one reference strain each of Mycoplasma pneumoniae and Mycoplasma hominis, respectively. All fluoroquinolones tested selected for resistance, with alterations affecting the quinolone resistance-determining regions of the four target topoisomerase genes.