Adenosine Monophosphate (AMP)-Activated Protein Kinase: A New Target for Nutraceutical Compounds.
Adenosine Monophosphate (AMP)-Activated Protein Kinase: A New Target for Nutraceutical Compounds.
复制标题
DOI：
10.3390/ijms18020288
复制
发表时间：
2017-01-29
影响因子：
5.6
通讯作者：
Cordero MD
中科院分区：
文献类型：
--
作者：
Marín-Aguilar F;Pavillard LE;Giampieri F;Bullón P;Cordero MD
一磷酸腺苷激活蛋白激酶（AMPK）是一种重要的能量传感器，它通过一磷酸腺苷（AMP）/三磷酸腺苷（ATP）比率和/或二磷酸腺苷（ADP）/ATP比率的增加而被激活，并增加脂肪酸氧化、葡萄糖转运和线粒体生物合成等不同代谢途径。从这个意义上说，AMPK通过诱导细胞内ATP酶和抑制ATP消耗的生物合成途径来维持细胞能量稳态，以保持ATP水平。一些研究表明，在衰老过程中AMPK对细胞应激的敏感性降低，这可能会损害下游信号传导和细胞能量平衡的维持以及应激抗性。然而，一些疾病与AMPK功能障碍有关。AMPK信号传导的改变降低线粒体生物发生，增加细胞应激并诱导炎症，这是衰老过程的典型事件，并与几种病理过程相关。在这个意义上，在过去的几年中，AMPK已被确定为一个非常有趣的目标，不同的营养化合物正在研究对AMPK诱导的有趣的潜在影响。本文综述了不同营养成分诱导AMPK磷酸化的相互作用及其在癌症、II型糖尿病、神经退行性疾病和心血管疾病中的应用。
Adenosine monophosphate-activated protein kinase (AMPK) is an important energy sensor which is activated by increases in adenosine monophosphate (AMP)/adenosine triphosphate (ATP) ratio and/or adenosine diphosphate (ADP)/ATP ratio, and increases different metabolic pathways such as fatty acid oxidation, glucose transport and mitochondrial biogenesis. In this sense, AMPK maintains cellular energy homeostasis by induction of catabolism and inhibition of ATP-consuming biosynthetic pathways to preserve ATP levels. Several studies indicate a reduction of AMPK sensitivity to cellular stress during aging and this could impair the downstream signaling and the maintenance of the cellular energy balance and the stress resistance. However, several diseases have been related with an AMPK dysfunction. Alterations in AMPK signaling decrease mitochondrial biogenesis, increase cellular stress and induce inflammation, which are typical events of the aging process and have been associated to several pathological processes. In this sense, in the last few years AMPK has been identified as a very interesting target and different nutraceutical compounds are being studied for an interesting potential effect on AMPK induction. In this review, we will evaluate the interaction of the different nutraceutical compounds to induce the AMPK phosphorylation and the applications in diseases such as cancer, type II diabetes, neurodegenerative diseases or cardiovascular diseases.