Relationship Between Measures of Adiposity, Arterial Inflammation, and Subsequent Cardiovascular Events.
Relationship Between Measures of Adiposity, Arterial Inflammation, and Subsequent Cardiovascular Events.
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DOI：
10.1161/circimaging.115.004043
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发表时间：
2016-04
期刊：
影响因子：
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通讯作者：
Tawakol A
中科院分区：
文献类型：
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作者：
Figueroa AL;Takx RA;MacNabb MH;Abdelbaky A;Lavender ZR;Kaplan RS;Truong QA;Lo J;Ghoshhajra BB;Grinspoon SK;Hoffmann U;Tawakol A
本研究的目的是评估不同的肥胖指标与动脉炎症和随后心血管事件风险的关系。我们纳入了接受 FDG PET/CT 成像以进行肿瘤学评估的个体。测定皮下脂肪组织（SAT）体积、内脏脂肪组织（VAT）体积和VAT/SAT比率。此外，还确定了 BMI、代谢综合征 (MetS) 和主动脉 FDG 摄取（动脉炎症的衡量标准）。裁定了心血管疾病（CVD）事件的后续发展。该分析包括 415 名患者，中位年龄为 55 岁（P25-P75：45-65），中位 BMI 为 26.4（P25-P75：23.4-30.9）kg/m2。肥胖者的增值税和 SAT 金额显着更高。 VAT 体积（r=0.290，p<0.001）和 VAT/SAT 比率（r=0.208，p<0.001）与动脉炎症呈正相关。 32 名受试者在中位随访 4 年期间经历了 CVD 事件。 Cox比例风险模型显示，VAT体积和VAT/SAT比率与CVD事件相关（风险比，HR（95% CI）：1.15（分别为1.06-1.25，p<0.001；3.60（1.88-6.92），p<0.001）。BMI、MetS和SAT不能预测CVD事件。内脏脂肪的测量呈正相关内脏脂肪含量较高且动脉炎症水平升高的个体发生后续 CVD 事件的风险最高。研究结果表明，动脉炎症可能解释了与肥胖相关的一些 CVD 风险。
The objective of this study was to evaluate how different measures of adiposity are related to both arterial inflammation and the risk of subsequent cardiovascular events. We included individuals who underwent FDG PET/CT imaging for oncological evaluation. Subcutaneous adipose tissue (SAT) volume, visceral adipose tissue (VAT) volume and VAT/SAT ratio were determined. Additionally BMI, metabolic syndrome (MetS), and, aortic FDG uptake (a measure of arterial inflammation) were determined. Subsequent development of cardiovascular disease (CVD) events was adjudicated. The analysis included 415 patients with a median age of 55 (P25–P75: 45–65) and a median BMI of 26.4 (P25– P75: 23.4–30.9) kg/m2. VAT and SAT volume were significantly higher in obese individuals. VAT volume (r=0.290, p<0.001) and VAT/SAT ratio (r=0.208, p<0.001) were positively correlated with arterial inflammation. 32 subjects experienced CVD event during a median follow-up of 4 years. Cox proportional hazard models showed that VAT volume, and VAT/SAT ratio were associated with CVD events (hazard ratio, HR (95% CI): 1.15 (1.06–1.25, p<0.001; 3.60 (1.88–6.92), p<0.001 respectively). BMI, MetS and SAT were not predictive of CVD events. Measures of visceral fat are positively related to arterial inflammation and are independent predictors of subsequent CVD events. Individuals with higher measures of visceral fat as well as elevated arterial inflammation are at highest risk for subsequent CVD events. The findings suggest that arterial inflammation may explain some of the CVD risk associated with adiposity.