Pergolide presynaptically inhibits calcium-stimulated release of gamma-aminobutyric acid.
Pergolide presynaptically inhibits calcium-stimulated release of gamma-aminobutyric acid.
复制标题
培高利特突触前抑制钙刺激的γ-氨基丁酸释放。
DOI：
10.1111/j.1471-4159.1991.tb06405.x
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发表时间：
1991
影响因子：
4.7
通讯作者：
Ungerstedt,U
中科院分区：
文献类型：
--
作者：
Drew,KL;Ungerstedt,U
采用在体微透析技术研究了大鼠纹状体背外侧区γ-氨基丁酸（GABA）的释放。在探针植入清醒、自由活动的大鼠后2天，使用改良的林格溶液进行透析。钙诱导GABA释放的可逆性增加被河豚毒素废除，但仅轻微衰减的最大有效剂量的培高利特，D2受体激动剂。因此得出结论，培高利特通过与河豚毒素不同的机制抑制钙刺激的GABA突触前释放。
The release of γ‐aminobutyric acid (GABA) in rat dorsolateral striatum was studied using in vivo microdialysis. Dialysis was conducted 2 days after probe implantation in awake, freely moving rats using a modified Ringer solution. Calcium induced a reversible increase in GABA release that was abolished by tetrodotoxin but was only slightly attenuated by a maximally effective dose of pergolide, a D2receptor agonist. It was thus concluded that pergolide inhibits calcium‐stimulated release of GABA presynaptically by a mechanism distinct from that of tetrodotoxin.