Regular treadmill running improves spatial learning and memory performance in young mice through increased hippocampal neurogenesis and decreased stress
Regular treadmill running improves spatial learning and memory performance in young mice through increased hippocampal neurogenesis and decreased stress
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定期在跑步机上跑步可以通过增加海马神经发生和减少压力来改善年轻小鼠的空间学习和记忆表现
DOI：
10.1016/j.brainres.2013.07.041
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发表时间：
2013-09-19
期刊：
影响因子：
2.9
通讯作者：
Yang, Bo
中科院分区：
文献类型：
--
作者：
Li, Hongwei;Liang, Aming;Yang, Bo
大量证据表明，跑步机跑步可以增强神经发生，改善认知功能，并保护大脑免受神经退行性疾病的影响。然而，跑步机跑步是一种强迫运动，可能会增加皮质酮的水平，从而下调神经发生并损害认知功能。本研究的目的是调查是否定期跑步机跑步提供了积极和消极的影响之间的平衡跑步机。将小鼠分为四组：对照组（CON）、规律跑步组（RR）、不规律持续时间跑步组（IDR）和不规律时间跑步组（ITR）。RR小鼠每天在跑步机上以相同的时间、速度和持续时间跑步。IDR小鼠以相同的时间和速度跑步，但持续时间不同。ITR小鼠以相同的速度和持续时间跑步，但在一天中的不同时间。结果表明，规律跑台运动能促进神经发生，提高空间学习记忆能力，并能降低皮质酮水平。本研究结果强调有规律的体育锻炼对认知的重要性。(c)2013爱思唯尔有限公司版权所有。
A substantial amount of evidence has shown that treadmill running enhances neurogenesis, improves cognitive function, and protects the brain against neurodegenerative disorders. However, treadmill running is a type of forced exercise that could increase the level of corticosterone, which subsequently down-regulates neurogenesis and impairs cognitive function. The purpose of this study was to investigate if regular treadmill running provides a balance between the positive and negative effects of treadmill running. The mice were divided into four groups: controls (CON), regular runners (RR), irregular duration runners (IDR) and irregular time-of-day runners (ITR). The RR mice ran daily on the treadmill at the same time-of-day, speed and duration. The IDR mice ran at the same time-of-day and speed, but for a different duration. The ITR mice ran at the same speed and duration, but at different time-of-day. The results showed that regular treadmill running could increase neurogenesis and improve spatial learning and memory performance, as well as decrease the level of corticosterone. The present finding emphasizes the importance of regular physical exercise on cognition. (c) 2013 Elsevier B.V. All rights reserved.