Independent coding of movement direction and reward prediction by single pallidal neurons
Independent coding of movement direction and reward prediction by single pallidal neurons
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DOI：
10.1523/jneurosci.2583-04.2004
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发表时间：
2004-11-10
影响因子：
5.3
通讯作者：
Bergman, H
中科院分区：
文献类型：
--
作者：
Arkadir, D;Morris, G;Bergman, H
将行动与其奖励值联系起来是适应性生物体所需的基本能力，需要边缘系统、运动和联想信息的融合。为了绘制出基底神经节 (BG) 参与这种关联的图表，我们记录了执行概率视觉运动任务的两只猴子的苍白球外节 (GPe) 中 61 个分离良好的神经元的活动。我们的结果表明大多数（96％）神经元对任务的多个阶段做出反应。许多（34％）苍白球神经元的活动仅由运动方向调节，而只有少数（3％）苍白球神经元的活动仅由奖励预测调节。然而，大量（41％）单个苍白球神经元的活动受到预期试验结果和手臂运动方向的共同调节。单个苍白球神经元的神经活动携带的信息随着试验的进展而动态变化。在试验开始时，该活动主要受到结果预测和未来运动方向的调节，并且在试验结束时主要受到运动方向的调节。 GPe 神经元可以根据预测的未来奖励增加或减少其放电率。运动方向和奖励概率对神经活动的影响是线性求和的，因此反映了苍白球活动的两个独立的调节。我们认为 GPe 神经元特别适合独立处理多个参数。这是通过 BG 架构的漏斗结构特征以及 GPe 神经元的解剖和生理特性实现的。
Associating action with its reward value is a basic ability needed by adaptive organisms and requires the convergence of limbic, motor, and associative information. To chart the basal ganglia ( BG) involvement in this association, we recorded the activity of 61 well isolated neurons in the external segment of the globus pallidus ( GPe) of two monkeys performing a probabilistic visuomotor task. Our results indicate that most ( 96%) neurons responded to multiple phases of the task. The activity of many ( 34%) pallidal neurons was modulated solely by direction of movement, and the activity of only a few ( 3%) pallidal neurons was modulated exclusively by reward prediction. However, the activity of a large number ( 41%) of single pallidal neurons was comodulated by both expected trial outcome and direction of arm movement. The information carried by the neuronal activity of single pallidal neurons dynamically changed as the trial progressed. The activity was predominantly modulated by both outcome prediction and future movement direction at the beginning of trials and became modulated mainly by movement - direction toward the end of trials. GPe neurons can either increase or decrease their discharge rate in response to predicted future reward. The effects of movement - direction and reward probability on neural activity are linearly summed and thus reflect two independent modulations of pallidal activity. We propose that GPe neurons are uniquely suited for independent processing of a multitude of parameters. This is enabled by the funnel - structure characteristic of the BG architecture, as well as by the anatomical and physiological properties of GPe neurons.