A novel saliva test for caries risk assessment.
A novel saliva test for caries risk assessment.
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DOI：
10.1080/19424396.2006.12222197
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发表时间：
2006-04
期刊：
影响因子：
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通讯作者：
P. Denny;P. Denny;Jona Takashima;Y. Si;M. Navazesh;Joyce M Galligan
中科院分区：
文献类型：
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作者：
P. Denny;P. Denny;Jona Takashima;Y. Si;M. Navazesh;Joyce M Galligan
本研究中引入的一种用于龋齿风险评估的新唾液测试整合了多种宿主因素来预测儿童、牙组特定的个体风险水平。这些不同的宿主因素与年轻人的龋病史、DFT（腐烂和填充的牙齿）或 DFS（腐烂和填充的表面）相关。该测试基于唾液糖蛋白上存在的基因确定的寡糖模式。据信，该测试背后的机制集中在特定的寡糖上，这些寡糖要么促进细菌在牙齿表面的附着和定植，要么通过促进凝集和去除游离细菌来防止定植。两类寡糖的比例与在年轻成年人群中观察到的 DFS 或 DFT 数值范围密切相关。
A new saliva test for caries risk assessment introduced in this study integrates a variety of host factors to predict for children, individual risk levels that are tooth-group specific. These various host factors correlate with caries history, DFT (decayed and filled teeth) or DFS (decayed and filled surfaces) in young adults. The test is based on the pattern of genetically determined oligosaccharides present on salivary glycoproteins. The mechanism behind the test is believed to be centered on the specific oligosaccharides that either facilitate bacterial attachment and colonization at the surface of teeth or protect against colonization by promoting agglutination and removal of free bacteria. It is the ratio of the two classes of oligosaccharides that is very strongly correlated with the numerical range of DFS or DFT observed in a young adult population.