THE GROWTH OF HAIR FOLLICLES IN WAVES *
THE GROWTH OF HAIR FOLLICLES IN WAVES *
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DOI：
10.1111/j.1749-6632.1960.tb40912.x
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发表时间：
1959-11
影响因子：
5.2
通讯作者：
H. B. Chase;G. J. Eaton
中科院分区：
文献类型：
--
作者：
H. B. Chase;G. J. Eaton
毛发生长的波动在几种哺乳动物中出现，如小鼠、大鼠、仓鼠、栗鼠和兔子，但在其他一些哺乳动物中并不常见，如豚鼠和人类。波动可以定义为毛囊进入生长期（即生长期）的时间和空间上的有序进展。当所有卵泡同时进入活动状态时，或者相反，当卵泡单独进入这一阶段，与相邻卵泡没有任何同步或关系时，存在非波情况。豚鼠的镶嵌型毛发替代是后一种情况的一个例子（Chase，1954），每个毛囊独立地以自己的频率进行生长周期。波的存在，即含有毛囊活动的皮肤区域的有序扩散，表明毛囊的相关性，这是由于共同的和扩散的引发剂作用于毛囊或通过某种方式使毛囊在其静止的邻居上生长的作用。活动的同步性也可以在没有波浪现象的情况下发生，就像老年小鼠的毛发生长的非扩散岛一样，这表明毛囊的相关性和相互依赖性，但静止的毛囊对它们正在生长的邻居的反应越来越不敏感或无力。因此，波动现象是一种介于同时活动岛的存在和整个动物同时活动的发生之间的中间状态。波的速度反映了每单位时间内在前进边缘之前变得活跃的静止卵泡的数量。一个活动区域的周边可能有一部分迅速延伸，而另一部分则完全不向前推进。两个波，特别是来自相对侧的波，可以合并，然后向前或向后行进，或两者兼而有之。一些区域保持静止（滞后区域），也就是说，在一代中不参与波，但可能是响应性的，并参与下一个毛发生成波的时间。本文对不同品系、不同年龄、不同生理条件的有色雄性和雌性小鼠的重复自发毛发生长波进行了观察。用电动剪刀仔细修剪完整的皮毛，通过皮肤中活跃的毛球的颜色来观察波浪的进展。每隔两天或更短的时间画出这些区域的轮廓，本文还将报道和总结从不同年龄的不同区域拔出静止的毛发和拔出不同大小区域的毛发诱导毛发生长的结果。共观察了230只品系为C57 BL、C57 BR、DBA和C3 H的小鼠。根据美国原子能委员会（华盛顿）AT（30-1）2018合同，C.的;合同4 F 29（600）-14？6架来自美国空军，华盛顿，D。C.
Waves of hair growth occur in several mammals, such as the mouse, rat, hamster, chinchilla, and rabbit, but do not occur as regular features in some other mammals: for example, the guinea pig and man. A wave may be defined as an orderly progression in time and space of follicles entering the growth phase, that is, anagen, of their cycles. A nonwave situation exists either when all follicles enter into activity simultaneously or, conversely, when follicles enter into this phase individually and without any synchronism or relationship with neighboring follicles. The mosaic type of hair replacement in the guinea pig is an example of the latter situation (Chase, 1954), each follicle proceeding through its growth cycle generations independently and with its own frequency. The presence of a wave, that is, the orderly spreading of the skin area containing follicular activity, indicates a correlation of follicles, due either to a common and spreading initiator acting on the follicles or to an action by some means of growing follicles on their resting neighbors. Synchronism of activity can also occur without the phenomenon of a wave, as in nonspreading islands of hair growth in older mice, indicating the correlation and interdependence of follicles, but an increasing refractoriness or inability of resting follicles to respond to the presence of their growing neighbors. The wave phenomenon is then an intermediate situation between the presence of an island of simultaneous activity and the occurrence of simultaneous activity over the whole animal. The rapidity of a wave is a reflection of the number of resting follicles ahead of the advancing edge that become active per unit time. An area of activity may have part of its periphery extending rapidly and another part not advancing a t all. Two waves, especially from opposite sides, may coalesce and then proceed anteriorly or posteriorly, or both. Some areas remain quiescent (lag areas), that is, do not become involved in a wave, for one generation, but may be responsive and participate a t the time of the next hair generation wave. Reported in this paper will be the observations on the repeated spontaneous hair growth waves in colored male and female mice of different strains, ages, and physiological conditions. The complete pelage was kept carefully clipped with electric clippers, the progress of waves being observed by the presence of color due to active hair bulbs in the skin. The outlines of these areas were drawn a t intervals of two days or less. Also reported and summarized in this paper will be the results of inducing hair growth by the plucking of resting hairs from different areas a t different ages and the plucking of areas of different sizes. A total of 230 mice of strains C57 BL, C57 BR, DBA, and C3H were observed * The work described in this paper was supported in part by Grant-in-Aid C-592 from the National Cancer Institute, Public Health Service, Bethesda, Md.; by Contract AT (30-1)2018 from the United States Atomic Energy Commission, Washington, D. C.; and by Contract 4 F 29 (600)-14?6 from the United States Air Force, Washington, D. C.