New and concise syntheses of the bicyclic oxamazin core using an intramolecular nitroso Diels-Alder reaction and ring-closing olefin metathesis.
New and concise syntheses of the bicyclic oxamazin core using an intramolecular nitroso Diels-Alder reaction and ring-closing olefin metathesis.
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使用分子内亚硝基狄尔斯-阿尔德反应和闭环烯烃复分解反应，新颖、简洁地合成双环恶嗪嗪核。
DOI：
10.1021/ol303305u
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发表时间：
2013
期刊：
影响因子：
5.2
通讯作者：
Miller,MarvinJ
中科院分区：
文献类型：
--
作者：
Watson,KyleD;Carosso,Serena;Miller,MarvinJ
本文报道了两种用于制备不饱和双环恶嗪嗪核的新且简明的合成方法。第一个涉及使用分子内狄尔斯-阿尔德反应一步形成两个稠合环。第二种方法在最终步骤中结合了闭环烯烃复分解以形成核的第二个稠合环。第二种方法的范围也进一步扩大，以提供更大的环状双环系统。
Herein two new and concise synthetic approaches for making an unsaturated bicyclic oxamazin core are reported. The first involves the use of an intramolecular Diels–Alder reaction to form both of the fused rings in one step. The second approach incorporates ring-closing olefin metathesis in the final step to form the second fused ring of the core. The scope of the second approach was also expanded further to afford larger ringed bicyclic systems.