Plasma Glycine and Risk of Acute Myocardial Infarction in Patients With Suspected Stable Angina Pectoris.
Plasma Glycine and Risk of Acute Myocardial Infarction in Patients With Suspected Stable Angina Pectoris.
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DOI：
10.1161/jaha.115.002621
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发表时间：
2015-12-31
影响因子：
5.4
通讯作者：
Nygård OK
中科院分区：
文献类型：
--
作者：
Ding Y;Svingen GF;Pedersen ER;Gregory JF;Ueland PM;Tell GS;Nygård OK
甘氨酸是一种氨基酸，参与抗氧化反应、嘌呤合成和胶原形成。几项研究表明，甘氨酸与肥胖、高血压和糖尿病呈负相关。最近，甘氨酸依赖的反应也被认为与脂代谢和胆固醇运输有关。然而，关于甘氨酸和冠心病之间的联系的证据很少。因此，我们评估了血浆甘氨酸与急性心肌梗死(AMI)的相关性。对4109名因疑似稳定型心绞痛而行冠状动脉造影术的患者进行了研究。COX回归用于评估血浆甘氨酸与急性心肌梗死之间的关联，这是通过与CVDNOR项目相关联而获得的。在中位数7.4年的随访中，616名患者(15.0%)经历了急性心肌梗死。女性的甘氨酸水平高于男性，与更有利的基线血脂水平和较低的肥胖、高血压和糖尿病患病率相关(均P<；0.001)。在对传统的冠心病危险因素进行多因素调整后，甘氨酸与急性心肌梗死的危险性呈负相关(每标准差危险比：0.89；95%可信区间：0.82~0.98；P=0.017)。在载脂蛋白B、低密度脂蛋白胆固醇或载脂蛋白A-1高于中位数的人群中，这种反向关联通常更强(均为P交互作用≤0.037)。在疑似稳定型心绞痛的患者中，血浆甘氨酸与急性心肌梗死的风险呈负相关。在载脂蛋白B、低密度脂蛋白胆固醇或载脂蛋白A-1水平高于中位数的患者中，相关性更强。这些结果推动了进一步的研究，以阐明甘氨酸和脂代谢的关系，特别是与胆固醇运输和动脉粥样硬化有关的关系。网址：https://www.clinicaltrials.gov.唯一标识：NCT00354081。
Glycine is an amino acid involved in antioxidative reactions, purine synthesis, and collagen formation. Several studies demonstrate inverse associations of glycine with obesity, hypertension, and diabetes mellitus. Recently, glycine‐dependent reactions have also been linked to lipid metabolism and cholesterol transport. However, little evidence is available on the association between glycine and coronary heart disease. Therefore, we assessed the association between plasma glycine and acute myocardial infarction (AMI). A total of 4109 participants undergoing coronary angiography for suspected stable angina pectoris were studied. Cox regression was used to estimate the association between plasma glycine and AMI, obtained via linkage to the CVDNOR project. During a median follow‐up of 7.4 years, 616 patients (15.0%) experienced an AMI. Plasma glycine was higher in women than in men and was associated with a more favorable baseline lipid profile and lower prevalence of obesity, hypertension, and diabetes mellitus (all P<0.001). After multivariate adjustment for traditional coronary heart disease risk factors, plasma glycine was inversely associated with risk of AMI (hazard ratio per SD: 0.89; 95% CI, 0.82–0.98; P=0.017). The inverse association was generally stronger in those with apolipoprotein B, low‐density lipoprotein cholesterol, or apolipoprotein A‐1 above the median (all P interaction≤0.037). Plasma glycine was inversely associated with risk of AMI in patients with suspected stable angina pectoris. The associations were stronger in patients with apolipoprotein B, low‐density lipoprotein cholesterol, or apolipoprotein A‐1 levels above the median. These results motivate further studies to elucidate the relationship between glycine and lipid metabolism, in particular in relation to cholesterol transport and atherosclerosis. URL: https://www.clinicaltrials.gov. Unique identifier: NCT00354081.