Organotypic Endothelial Cell Surface Molecules Mediate Organ Preference of Metastasis
Organotypic Endothelial Cell Surface Molecules Mediate Organ Preference of Metastasis
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器官型内皮细胞表面分子介导转移的器官偏好
DOI：
10.1007/978-1-4899-0721-9_26
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发表时间：
1992
影响因子：
--
通讯作者：
M. El
中科院分区：
文献类型：
--
作者：
B. Pauli;R. C. Johnson;M. El
转移瘤是指恶性原发肿瘤通过播散在远处的多器官部位形成的肿瘤菌落。尽管远端转移最常见的器官部位是血源性肿瘤细胞首先遇到的器官，但许多癌症转移到与循环肿瘤细胞进入的初始器官无关的部位，因此，表现出独特的器官定植模式，不符合肿瘤细胞传播的简单解剖-机械捕获理论。1-7例如，乳腺腺癌经常转移到肝脏、骨骼、大脑和肾上腺，除了预期的转移到肺部的高发病率外，前列腺癌最常转移到骨骼。这种非随机的转移模式是由Paget首先描述的，8他倡导转移扩散的“种子和土壤”假说。他假设总体肿瘤的发展是提供肥沃环境（土壤）的结果，相容的肿瘤细胞（种子）可以在土壤中增殖大量关于优先转移机制的研究表明，肿瘤细胞在次要器官部位的植入、侵袭、存活和生长取决于许多肿瘤细胞和宿主的特征，这些特征为转移的发生提供了适当的细胞和基质环境
Metastases are tumor colonies that develop in distant, often multiple organ sites by dissemination from a malignant primary tumor. Although the most frequent organ sites of distant metastases are the first organs encountered by blood-borne tumor cells, many cancers metastasize to sites which are unrelated to the initial organ entered by circulating tumor cells and, thus, display unique organ colonization patterns that do not fit simple, anatomical-mechanical trapping theories of tumor cell dissemination.1–7 For example, breast adenocarcinomas metastasize frequently to liver, bone, brain, and adrenals, in addition to the expected, high incidence of metastasis to the lungs, and carcinomas of the prostate metastasize most often to bone. This nonrandom pattern of metastasis was first described by Paget,8 who championed the “seed and soil” hypothesis of the metastatic spread. He postulated that gross tumor development was a consequence of the provision of a fertile environment (the soil) in which compatible tumor cells (the seeds) could proliferate.4 Numerous studies on the mechanisms of preferential metastasis have since shown that tumor cell implantation, invasion, survival, and growth at secondary organ sites depend upon a number of tumor cell and host characteristics that provide the proper cellular and stromal environment for metastasis to develop.9–16
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内皮细胞膜囊泡在转移器官偏好研究中的作用。
影响因子：
11.2
作者：
Johnson,RC;Augustin-Voss,HG;Zhu,DZ;Pauli,BU
通讯作者：
Pauli,BU
小鼠肿瘤细胞与毛细血管内皮之间粘附的特异性：体内优先转移的体外相关性。
影响因子：
11.2
作者：
Auerbach,R;Lu,WC;Pardon,E;Gumkowski,F;Kaminska,G;Kaminski,M
通讯作者：
Kaminski,M
开发用于侵袭研究的体外和体内上皮肿瘤模型。
影响因子：
11.2
作者：
Pauli,BU;Anderson,SN;Memoli,VA;Kuettner,KE
通讯作者：
Kuettner,KE
影响因子：
56.9
作者：
RICE, GE;BEVILACQUA, MP
通讯作者：
BEVILACQUA, MP
转移的器官偏好。
DOI：
--
发表时间：
1988
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Pauli,BU;Lee,CL
通讯作者：
Lee,CL