Risk factors for gastric cancer in Japan in the 2010s: a large, long-term observational study
Risk factors for gastric cancer in Japan in the 2010s: a large, long-term observational study
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DOI：
10.1007/s10120-021-01273-7
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发表时间：
2022-01-24
期刊：
影响因子：
7.4
通讯作者：
Fujishiro, Mitsuhiro
中科院分区：
文献类型：
--
作者：
Takahashi, Yu;Yamamichi, Nobutake;Fujishiro, Mitsuhiro
背景在日本，幽门螺杆菌（HP）感染的个体和死亡的人数在日本减少。我们旨在确定慢性胃炎的血清学检测（ABC方法）是否仍然对2010年代的胃癌风险分层有用，并分析日本发展胃癌的风险因素。在这项前瞻性研究中，我们从2010年至2019年监测了20773个人的胃癌发病率。分析了2010年的血液抽样结果，体格检查和生活方式与胃癌累积发生率之间的关系。结果总共分析了符合研究标准的19343名参与者。总体而言，A组参与者的0.08％（9/11717），B组（28/4452）的0.63％，C组为2.05％（43/2098），D组为1.52％（1/66）和0.30 E组（3/1010）中的％出现了胃癌。 Cox危害分析表明，年龄> = 50岁。根据ABC方法B组，C和D组；目前的吸烟习惯是胃癌的独立危险因素。胃癌发病率的危害比（HRS）为6.7，在C组中为21.7，而E组的HRS为2.8，与A组A的危险率为2.8，胃癌的发生率没有显着差异。在随访期间，在B组，C和D中成功消除HP的患者之间在统计学上没有显着差异。结论ABC方法在2010年代仍然对胃癌风险分层有用。
Background The numbers of Helicobacter pylori (HP)-infected individuals and deaths due to gastric cancer are decreasing in Japan. We aimed to determine whether the serological test for chronic gastritis (the ABC method) is still useful for gastric cancer risk stratification in the 2010s and to analyze risk factors for developing gastric cancer in Japan. Methods In this prospective study, we monitored 20773 individuals for the incidence of gastric cancer from 2010 to 2019. The relationships between blood sampling results, physical examination, and lifestyle in 2010 and the cumulative incidence of gastric cancer were analyzed. Results A total of 19343 participants who met the study criteria were analyzed. Overall, 0.08% of participants in group A (9/11717), 0.63% in group B (28/4452), 2.05% in group C (43/2098), 1.52% in group D (1/66), and 0.30% in group E (3/1010) developed gastric cancer. Cox hazard analysis showed that age >= 50 years; groups B, C, and D according to the ABC method; and current smoking habits were independent risk factors for gastric cancer. The hazard ratios (HRs) of the incidence of gastric cancer were 6.7 in group B and 21.7 in groups C and D, while the HRs of group E was 2.8, which was not significantly different from that of group A. The incidence of gastric cancer was not statistically significantly different between those with and without successful HP eradication in groups B, C, and D during follow-up. Conclusions The ABC method was still useful for gastric cancer risk stratification in the 2010s.