The expanding repertoire of receptor activity modifying protein (RAMP) function.
The expanding repertoire of receptor activity modifying protein (RAMP) function.
复制标题
DOI：
10.3109/10409238.2015.1128875
复制
发表时间：
2016
影响因子：
6.5
通讯作者：
Caron KM
中科院分区：
文献类型：
--
作者：
Klein KR;Matson BC;Caron KM
受体活性修饰蛋白（RAMP）与质膜上的G蛋白偶联受体（GPCR）结合，并与多种肽配体结合在一起，作为细胞外和细胞内环境之间的通讯界面。RAMP相互作用的GPCR的集合继续扩大，现在由来自家族A、B和C的GPCR组成，表明RAMP活性非常普遍。RAMP与GPCR的结合可以通过改变配体结合、受体运输和脱敏以及下游信号传导途径来调节GPCR功能。在这里，我们详细阐述了这些RAMP依赖的GPCR调节机制，这为药物干预提供了机会。
Receptor activity modifying proteins (RAMPs) associate with G-protein-coupled receptors (GPCRs) at the plasma membrane and together bind a variety of peptide ligands, serving as a communication interface between the extracellular and intracellular environments. The collection of RAMP-interacting GPCRs continues to expand and now consists of GPCRs from families A, B, and C, suggesting that RAMP activity is extremely prevalent. RAMP association with GPCRs can regulate GPCR function by altering ligand binding, receptor trafficking and desensitization, and downstream signaling pathways. Here, we elaborate on these RAMP-dependent mechanisms of GPCR regulation, which provide opportunities for pharmacological intervention.