Fluorescent properties of novel dendrimer dyes based on thiazole orange
Fluorescent properties of novel dendrimer dyes based on thiazole orange
复制标题
基于噻唑橙的新型树枝状染料的荧光特性
DOI：
10.1016/j.jlumin.2011.05.017
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发表时间：
2011-10
影响因子：
3.6
通讯作者：
Fei, Xuening
中科院分区：
文献类型：
--
作者：
Gu, Yingchun;Shi, Bin;Lan, Yunquan;Fei, Xuening
本文以商品化的氨基乙醛缩二乙醇为原料，采用发散法合成了几代（G=0.5 ~ 2）含活性氨基的聚酰胺-胺（PAMAM）树枝状大分子。然后将含-COOH的噻唑橙子（TO）与G =1和2的树枝状大分子结合得到新型的树枝状大分子-TO染料。荧光性质的研究表明，相同浓度的树枝状大分子TO（G=2）的荧光强度比树枝状大分子TO（G=1）的荧光强度高，且两者都比含有-COOH的游离TO强得多。与游离染料相比，树枝状大分子染料的荧光增强。树枝状大分子染料化学结构明确，聚集和自猝灭少，具有稳定性好、强度高、灵敏度高的荧光特性，可用于标记癌细胞，进而用于早期肿瘤的诊断和检测。
In this paper, polyamidoamine (PAMAM) dendrimers with active amino group of some generations (G=0.5–2) were prepared from commercial aminoacetaldehyde diethyl acetal by the divergent method. After that, thiazole orange (TO) with –COOH was incorporated with dendrimers ofG=1 and 2 to afford novel dendrimer-TO dyes. The fluorescent properties studies showed that the fluorescent intensity of the same concentration of dendrimer-TO (G=2) was higher than that of the dendrimer-TO (G=1), and both of them were much stronger than free TO with –COOH. There was a fluorescent enhancement of the dendrimer dyes compared with free dye. The dendrimer dyes were of well-defined chemical structure,with little aggregation and self-quenching as well as good fluorescence properties of good stability, high intensity and sensitivity, which could be used in labeling cancer cells and further in diagnosis and detection of early-stage tumors.
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影响因子：
5.5
作者：
M. Winnik;S. Bystryak;J. Siddiqui
通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
D. Seebach;A. Beck;A. Heckel
影响因子：
5.5
作者：
M. Winnik;and Simon M. Bystryak;Zhaoqing Liu;J. Siddiqui
通讯作者：
M. Winnik;and Simon M. Bystryak;Zhaoqing Liu;J. Siddiqui