SARS-Cov-2 infection in transplant-related biology: Where do we stand?
SARS-Cov-2 infection in transplant-related biology: Where do we stand?
复制标题
移植相关生物学中的 SARS-CoV-2 感染：我们的立场如何？
DOI：
10.12659/aot.924768
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发表时间：
2020-12-29
影响因子：
1.1
通讯作者：
Gong W
中科院分区：
文献类型：
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作者：
Kong D;Li M;Gong W
2019年12月以来，新型冠状病毒（SARS-CoV-2）在武汉出现并迅速蔓延至全球。全球有近3 951 905例新型冠状动脉肺炎确诊病例，超过275 067例死亡，[JHU数据-09/05/2020，https：//www.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6]。大量患者感染了SARS-Cov-2肺炎（COVID-19）。SARS-CoV-2通过受体血管紧张素转换酶II（ACE 2）侵入人体靶细胞，ACE 2在肺、肾和回肠中表达，介导炎症反应和免疫活性。在感染患者中检测到高水平的促炎细胞因子。这些因素可能使移植患者易患不良结局的高风险。因此，移植患者可能会受到这种冠状病毒感染的影响，在这次疫情期间应特别注意保护同种异体移植物。在本研究中，我们试图描绘移植相关的SARS-CoV-2感染的生物学。
Since December 2019, the novel coronavirus (SARS-CoV-2) emerged in Wuhan and rapidly spread throughout the world. There are nearly 3 951 905 confirmed cases of novel coronary pneumonia and more than 275 067 deaths worldwide, [JHU data-09/05/2020, https://www.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6]. A great number of patients contracted SARS-Cov-2 pneumonia (COVID-19). SARS-CoV-2 invades human target cells through receptor angiotensin-converting enzyme II (ACE2), which are expressed in the lung, kidney, and ileum and mediate inflammatory responses and immune activities. High plasma levels of proinflammatory cytokines were detected in the infected patients. These factors may predispose transplant patients to high risk of poor outcomes. Therefore, transplant patients might be affected by this coronavirus infection and protection of allografts should receive special attention during this outbreak. In the present study we attempt to delineate the transplant-related biology of SARS-CoV-2 infection.