Effects of age and blood pressure on the retinal arterial wall, analyzed using adaptive optics scanning laser ophthalmoscopy.
Effects of age and blood pressure on the retinal arterial wall, analyzed using adaptive optics scanning laser ophthalmoscopy.
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DOI：
10.1038/srep12283
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发表时间：
2015-07-20
影响因子：
4.6
通讯作者：
Yoshimura N
中科院分区：
文献类型：
--
作者：
Arichika S;Uji A;Ooto S;Muraoka Y;Yoshimura N
血管的壁腔比（WLR）是视网膜微血管变化的一个有前途的早期标志物。最近，自适应光学扫描激光检眼镜（AOSLO）能够直接和非侵入性的动脉壁的可视化。应用AOSLO分析51例正常人WLR与年龄的相关性。此外，在73名受试者（51名正常人和22名高血压患者）中分析了血压与WLR之间的相关性。WLR与年龄呈强相关（r = 0.68，P < 0.0001），而正常组的外径和内径与年龄无显著相关性（分别为r = 0.13，P = 0.36和r =-0.12，P = 0.41）。正常组和高血压组WLR与收缩压和舒张压均呈强相关（r = 0.60，P < 0.0001和r = 0.65，P < 0.0001）。总之，AOSLO提供了无创和可重复的动脉测量。WLR是由于年龄和血压引起的视网膜动脉形态变化的早期标志。
The wall-to-lumen ratio (WLR) of the vasculature is a promising early marker of retinal microvascular changes. Recently, adaptive optics scanning laser ophthalmoscopy (AOSLO) enabled direct and noninvasive visualization of the arterial wall. Using AOSLO, we analyzed the correlation between age and WLR in 51 normal subjects. In addition, correlations between blood pressure and WLR were analyzed in 73 subjects (51 normal subjects and 22 hypertensive patients). WLR showed a strong correlation with age (r = 0.68, P < 0.0001), while outer diameter and inner diameter did not show significant correlation with age in the normal group (r = 0.13, P = 0.36 and r = −0.12, P = 0.41, respectively). In the normal and hypertensive groups, WLR showed a strong correlation with systolic and diastolic blood pressure (r = 0.60, P < 0.0001 and r = 0.65, P < 0.0001, respectively). In conclusion, AOSLO provided noninvasive and reproducible arterial measurements. WLR is an early marker of morphological changes in the retinal arteries due to age and blood pressure.