The Long and Short of MicroRNAs in the Kidney
The Long and Short of MicroRNAs in the Kidney
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DOI：
10.1681/asn.2011080797
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发表时间：
2012-03-01
影响因子：
13.6
通讯作者：
Kreidberg, Jordan A.
中科院分区：
文献类型：
--
作者：
Ho, Jacqueline;Kreidberg, Jordan A.
microRNAs（miRNAs）是一类小的非编码RNA，通过转录后抑制其靶mRNA的表达来调节基因的表达。miRNAs参与多种生物学过程，据估计，所有转录物中有多达一半受miRNAs调控。最近的研究也表明了miRNA在肾脏发育、生理学和病理生理学中的关键作用。了解miRNAs在肾脏中的功能可能会导致肾脏疾病的创新方法。
MicroRNAs (miRNAs) are a group of small, noncoding RNAs that act as novel regulators of gene expression through the post-transcriptional repression of their target mRNAs. miRNAs have been implicated in diverse biologic processes, and it is estimated that up to half of all transcripts are regulated by miRNAs. Recent studies also demonstrate a critical role for miRNAs in renal development, physiology, and pathophysiology. Understanding the function of miRNAs in the kidney may lead to innovative approaches to renal disease.