AN AMPLIFIED SENSITIVITY ARISING FROM COVALENT MODIFICATION IN BIOLOGICAL-SYSTEMS
AN AMPLIFIED SENSITIVITY ARISING FROM COVALENT MODIFICATION IN BIOLOGICAL-SYSTEMS
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DOI：
10.1073/pnas.78.11.6840
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发表时间：
1981-01-01
期刊：
影响因子：
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通讯作者：
KOSHLAND, DE
中科院分区：
文献类型：
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作者：
GOLDBETER, A;KOSHLAND, DE
检查可逆共价修饰系统的瞬态和稳态行为。当修饰酶在一级动力学区域之外操作时，控制任一修饰酶的效应物浓度的小百分比变化可以使修饰蛋白质的量产生大得多的百分比变化。这种对刺激的反应的放大可以在生物控制中提供额外的敏感性，相当于具有高希尔系数的变构蛋白。
The transient and steady-state behavior of a reversible covalent modification system is examined. When the modifying enzymes operate outside the region of first-order kinetics, small percentage changes in the concentration of the effector controlling either of the modifying enzymes can give much larger percentage changes in the amount of modified protein. This amplification of the response to a stimulus can provide additional sensitivity in biological control, equivalent to that of allosteric proteins with high Hill coefficients.