Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates.
Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates.
复制标题
II型胶原蛋白诱导的小鼠关节炎。 I.主要的组织相容性复合物（I区域）链接和抗体相关。
DOI：
10.1084/jem.154.3.688
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发表时间：
1981-09-01
影响因子：
15.3
通讯作者：
David, C S
中科院分区：
文献类型：
--
作者：
Wooley, P H;Luthra, H S;Stuart, J M;David, C S
通过将II型胶原注射到小鼠中来建立关节炎模型。只有携带H-2 q单倍型的小鼠对该疾病易感。通过使用Iq基因座上的重组菌株进一步绘制了易感性。II型胶原性关节炎在（抗性X易感）F1杂交中观察到。根据放射免疫测定法测定的抗II型抗体水平，将小鼠品系指定为高、中或低应答者。关节炎易感菌株均被归类为高抗体应答者。小鼠II型胶原性关节炎的临床和组织学表现表明，它可能是一个很好的动物模型，为研究各种免疫遗传学性状的类风湿性关节炎。
A model of arthritis was established by the injection of type II collagen into mice. Only mice bearing the H-2q haplotype were susceptible to the disease. Susceptibility was further mapped by the use of recombinant strains on the Iq locus. Type II collagen arthritis was observed in the (resistant X susceptible) F1 cross. Mice strains were designated high, intermediate, or low responders with respect to the anti-type II antibody levels measured by radioimmunoassay. Arthritis-susceptible strains were all classified as high antibody responders. The clinical and histological appearance of type II collagen arthritis in the mouse indicates that it may be a good animal model for the investigation of various immunogenetic traits in rheumatoid arthritis.