On the sites of the negative and positive feedback actions of estradiol in the control of gonadotropin secretion in the rhesus monkey.
On the sites of the negative and positive feedback actions of estradiol in the control of gonadotropin secretion in the rhesus monkey.
复制标题
雌二醇在控制恒河猴促性腺激素分泌中的负反馈和正反馈作用位点。
DOI：
10.1210/endo-102-4-1008
复制
发表时间：
1978
期刊：
影响因子：
4.8
通讯作者：
E. Knobil
中科院分区：
文献类型：
--
作者：
Y. Nakai;T. Plant;D. Hess;E. Keogh;E. Knobil
切除卵巢的恒河猴下丘脑病变已经消除了内源性LHRH的产生，促性腺激素分泌明显减少，但通过慢性间歇静脉注射合成LHRH（1微克/分钟，每小时6分钟）来重建LH和FSH分泌，研究雌二醇在控制促性腺激素分泌中的负反馈和正反馈作用的部位。对这些动物施用雌二醇，同时继续使用LHRH替代方案，导致循环LH和FSH水平下降，随后这些激素明显排出。这种促性腺激素分泌双相模式的时间过程与雌二醇在其他完整的卵巢切除动物中观察到的反应非常相似。这些结果表明，在恒河猴体内，雌二醇可以在垂体水平对促性腺激素的分泌同时发挥负反馈和正反馈作用。
Ovariectomized rhesus monkeys bearing hypothalamic lesions which had abolished endogenous LHRH production, as evidenced by a profound reduction in gonadotropin secretion, but in which LH and FSH secretion was reestablished by a chronic intermittent iv infusion of synthetic LHRH (1 microgram/min for 6 min every hour) were used to investigate the sites of the negative and positive feedback actions of estradiol in the control of gonadotropin secretion. The administration of estradiol to such animals, while continuing the LHRH replacement regimen, resulted in a decline in circulating LH and FSH levels, followed by an unambiguous discharge of these hormones. The time course of this biphasic pattern of gonadotropin secretion was remarkably similar to that observed in response to estradiol administration in otherwise intact ovariectomized animals. These results suggest that, in the rhesus monkey, estradiol can exert both its negative and positive feedback actions on gonadotropin secretion at the level of the pituitary gland.