Determination of the thermo-physical properties of multi-layered biological tissues
Determination of the thermo-physical properties of multi-layered biological tissues
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多层生物组织热物理性质的测定
DOI：
10.1016/j.apm.2021.06.006
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发表时间：
2021
影响因子：
5
通讯作者：
J. Niesen
中科院分区：
文献类型：
--
作者：
M. Alosaimi;D. Lesnic;J. Niesen
异常生物组织具有未知的特性，必须对其进行估计，以便根据剂量和适当的接种部位决定适当的治疗方法。目前的工作数值研究，第一次，从内部温度测量的多层组织的几个热物理性质的同时估计。组织内的热传播由生物热传递的热波模型建模，考虑到热传播的有限速度。在皮肤表面上，考虑到与环境的热交换，对流边界条件成立，而在组织的最内壁上，规定了狄利克雷边界温度条件。准确和稳定的重建的分段常数的热导率，热容和血液灌注率的属性成功地实现了两个物理的例子，关于三层和四层，一维组织，受到外部诱导的侵略。
Abnormal biological tissues possess unknown properties that must be estimated in order to decide the appropriate method of treatment in terms of amount of dosage and appropriate place of inoculation. The current work numerically investigates, for the first time, the simultaneous estimation of several thermo-physical properties of multi-layered tissues from internal temperature measurements. The heat propagation within the tissues is modelled by the thermal-wave model of bio-heat transfer, accounting for the finite speed of heat propagation. On the skin surface, a convective boundary condition holds taking into account the heat exchange with the environment, whilst on the most inner wall of the tissues a Dirichlet boundary temperature condition is prescribed. Accurate and stable reconstruction of the piecewise constant properties given by the thermal conductivity, heat capacity and blood perfusion rate is successfully achieved for two physical examples concerning three- and four-layered, one-dimensional tissues, subjected to externally induced aggression.